Literature summary for 2.7.7.48 extracted from

Paeshuyse, J.; Chezal, J.M.; Froeyen, M.; Leyssen, P.; Dutartre, H.; Vrancken, R.; Canard, B.; Letellier, C.; Li, T.; Mittendorfer, H.; Koenen, F.; Kerkhofs, P.; De Clercq, E.; Herdewijn, P.; Puerstinger, G.; Gueiffier, A.; Chavignon, O.; Teulade, J.C.; Neyts, J.
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication (2007), J. Virol., 81, 11046-11053.

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Bovine viral diarrhea virus 1

Protein Variants	Comment	Organism
E291G	mutant is insensitive against inhibitor ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate	Bovine viral diarrhea virus 1
F224S	mutant is insensitive against inhibitors ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate, 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine, and VP32947	Bovine viral diarrhea virus 1

Inhibitors	Comment	Organism
1-[2-(diethylamino)ethyl]-6-(1H-imidazol-1-yl)-1,3-dihydro-2H-benzimidazol-2-one	-	Bovine viral diarrhea virus 1
5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine	-	Bovine viral diarrhea virus 1
ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate	AG110, potent inhibitor of pestivirus replication, does not inhibit the in vitro activity of recombinant bovine viral diarrhea virus RdRp but inhibits the activity of bovine viral diarrhea virus replication complexes	Bovine viral diarrhea virus 1
N-propyl-N-[2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)ethyl]-1-propanamine	VP32947	Bovine viral diarrhea virus 1

Organism	UniProt	Comment	Textmining
Bovine viral diarrhea virus 1	P19711	strains Marloie, NADL, and 3435	-

Purification (Comment)	Organism
-	Bovine viral diarrhea virus 1

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Bovine viral diarrhea virus 1	diphosphate + RNAn+1	-	?

Synonyms	Comment	Organism
RDRP	-	Bovine viral diarrhea virus 1
RNA-dependent RNA polymerase	-	Bovine viral diarrhea virus 1