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Literature summary for 2.7.7.48 extracted from

  • Donner, P.L.; Xie, Q.; Pratt, J.K.; Maring, C.J.; Kati, W.; Jiang, W.; Liu, Y.; Koev, G.; Masse, S.; Montgomery, D.; Molla, A.; Kempf, D.J.
    Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase (2008), Bioorg. Med. Chem. Lett., 18, 2735-2738.
    View publication on PubMed
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
N-(3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-[(1E)-pent-1-en-1-yl]-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
-
 Hepacivirus C
N-(3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-[(1E)-prop-1-en-1-yl]-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
-
 Hepacivirus C
N-(3-[4-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
-
 Hepacivirus C
N-(3-[5-[(1E)-3,3-dimethylbut-1-en-1-yl]-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
-
 Hepacivirus C
N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-thiophen-2-yl-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[5-acetyl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[5-bromo-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[5-ethenyl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C
N-[3-[5-furan-2-yl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
-
 Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
 genotypes 1a and 1b
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
NS5B RNA-dependent RNA polymerase
-
 Hepacivirus C
RDRP
-
 Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000002
-
-
 Hepacivirus C N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000006
-
-
 Hepacivirus C N-(3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-[(1E)-prop-1-en-1-yl]-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
0.000008
-
-
 Hepacivirus C N-[3-[5-furan-2-yl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000011
-
-
 Hepacivirus C N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-thiophen-2-yl-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000024
-
-
 Hepacivirus C N-[3-[5-ethenyl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000055
-
-
 Hepacivirus C N-[3-[5-bromo-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000067
-
-
 Hepacivirus C N-(3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-[(1E)-pent-1-en-1-yl]-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
0.000274
-
-
 Hepacivirus C N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.00028
-
-
 Hepacivirus C N-[3-[5-acetyl-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.000406
-
-
 Hepacivirus C N-(3-[5-[(1E)-3,3-dimethylbut-1-en-1-yl]-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide
0.000425
-
-
 Hepacivirus C N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
0.00048
-
-
 Hepacivirus C N-(3-[4-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]-1-(3-methylbutyl)-2-oxo-1,2-dihydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)methanesulfonamide