Protein Variants | Comment | Organism |
---|---|---|
additional information | removal of the C21 domain enhances the enzyme stability. Whereas RNA synthesis by the full-length enzyme remains relatively constant at 12-100 mM KCl, synthesis by DELTA21 truncation mutatnt rapidly decreases at KCl concentrations greater than 12 mM. Binding by DELTA21 mutant but not full-length enzyme decreases proportionally as the KCl concentration increases from 25 to 200 mM. The truncation mutant becomes severely inhibited at elevated NTP concentrations, which most likely is due to competitive binding of the noncomplementary nucleotide to the polymerase catalytic center | Hepacivirus C |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Hepacivirus C | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS5B RdRp | - |
Hepacivirus C |