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Literature summary for 2.7.7.48 extracted from
- Function and structure in ribonucleic acid Phage Qbeta ribonucleic acid replicase. Effect of inhibitors of EF-Tu on ribonucleic acid synthesis and renaturation of active enzyme (1976), J. Biol. Chem., 251, 2749-2753.
General Stability
| General Stability | Organism |
|---|---|
| the EF-Tu*Ts complex rather than the individual polypeptides functions in the renaturation of Qbeta replicase, treatment of pure EF-Tu with kiromycin prevents it from functioning in the renaturation of Qbeta replicase | Qubevirus durum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| delvomycin | the protein synthetic activity of the EF-Tu in the replicase complex is eliminated but the Qbeta RNA replicase activity is only slightly affected | Qubevirus durum |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | Qubevirus durum | composed of one phage-coded polypeptide and three host-supplied polypeptides which function in the biosynthesis of proteins in the uninfected host. Two of theses polypeptides, protein elongation factors EF-Tu and EF-Ts, are required for initiation of transcription by replicase with all templates | diphosphate + RNAn+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Qubevirus durum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | - |
Qubevirus durum | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | composed of one phage-coded polypeptide and three host-supplied polypeptides which function in the biosynthesis of proteins in the uninfected host. Two of theses polypeptides, protein elongation factors EF-Tu and EF-Ts, are required for initiation of transcription by replicase with all templates | Qubevirus durum | diphosphate + RNAn+1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | composed of one phage-coded polypeptide and three host-supplied polypeptides | Qubevirus durum |
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