Literature summary for 2.7.7.47 extracted from

Shahi, S.K.; Singh, V.K.; Kumar, A.; Gupta, S.K.; Singh, S.K.
Interaction of dihydrofolate reductase and aminoglycoside adenyltransferase enzyme from Klebsiella pneumoniae multidrug resistant strain DF12SA with clindamycin: a molecular modelling and docking study (2013), J. Mol. Model., 19, 973-983.

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Application

Application	Comment	Organism
medicine	Klebsiella pneumoniae strains carrying the enzyme gene and a dihydrofolate reductase gene confering resistance to trimethoprim were found in eight out of 44 different diabetic foot ulcer patients	Klebsiella pneumoniae

Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of enzyme structure	Klebsiella pneumoniae

Inhibitors

Inhibitors	Comment	Organism	Structure
clindamycin	residues Phe34, Asp60, Arg63, Gln64, Leu68, Glu87, Thr89, Val90 are responsible for positioning clindamycin into the active site	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	P08881	-	-

Synonyms

Synonyms	Comment	Organism
aadA	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)