Inhibitors | Comment | Organism | Structure |
---|---|---|---|
neomycin | non-competitive versus streptomycin and uncompetitive versus ATP | Escherichia coli | |
tobramycin | non-competitive versus streptomycin and uncompetitive versus ATP | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + streptomycin | Escherichia coli | important mechanism of streptomycin modification is through ATP-dependent O -adenylation | diphosphate + 3''-adenylylstreptomycin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + streptomycin | important mechanism of streptomycin modification is through ATP-dependent O -adenylation | Escherichia coli | diphosphate + 3''-adenylylstreptomycin | - |
? | |
ATP + streptomycin | sequential mechanism, ordered substrate binding where ATP binds first and then streptomycin and diphosphate is released prior to formation of AMP-streptomycin | Escherichia coli | diphosphate + 3''-adenylylstreptomycin | - |
? |