Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.46 extracted from

  • Gates, C.A.; Northrop, D.B.
    Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism (1988), Biochemistry, 27, 3826-3833.
    View publication on PubMed
Search for more literature for 2.7.7.46

Application

Application Comment Organism
medicine application of alternative substrate diagnostic Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
neomycin C dead-end inhibition, uncompetitive versus MgATP2- Escherichia coli
sisomicin uncompetitive substrate inhibition Escherichia coli
tobramycin substrate inhibition, uncompetitive versus MgATP2- Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli W677/pMY10
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + gentamicin A gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors Escherichia coli diphosphate + 2''-adenylylgentamicin A
-
 r
ATP + gentamicin A gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors Escherichia coli W677/pMY10 diphosphate + 2''-adenylylgentamicin A
-
 r
ATP + gentamicin C1 gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors Escherichia coli diphosphate + 2''-adenylylgentamicin C1
-
 ?
ATP + gentamicin C1 gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors Escherichia coli W677/pMY10 diphosphate + 2''-adenylylgentamicin C1
-
 ?
ATP + gentamicin C1a gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors Escherichia coli diphosphate + 2''-adenylylgentamicin C1a
-
 ?
ATP + neomycin C
-
 Escherichia coli diphosphate + 2''-adenylylneomycin C
-
 r
ATP + neomycin C
-
 Escherichia coli W677/pMY10 diphosphate + 2''-adenylylneomycin C
-
 r
ATP + sisomicin
-
 Escherichia coli diphosphate + 2''-adenylylsisomicin
-
 r
ATP + sisomicin
-
 Escherichia coli W677/pMY10 diphosphate + 2''-adenylylsisomicin
-
 r
ATP + tobramycin
-
 Escherichia coli diphosphate + 2''-adenylyltobramycin
-
 r
ATP + tobramycin
-
 Escherichia coli W677/pMY10 diphosphate + 2''-adenylyltobramycin
-
 r

Synonyms

Synonyms Comment Organism
aminoglycoside nucleotidyltransferase 2''-I
-
 Escherichia coli
ANT(2'')-I
-
 Escherichia coli