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Literature summary for 2.7.7.43 extracted from

  • Knorst, M.; Fessner, W.D.
    CMP-sialate synthetase from Neisseria meningitidis - overexpression and application to the synthesis of oligosaccharides containing modified sialic acids (2001), Adv. Synth. Catal., 343, 698-710.
No PubMed abstract available

Application

Application Comment Organism
synthesis the high expressivity of the recombinant production clone, the high catalytic efficiency of the enzyme, and its broad substrate tolerance make this enzyme the preferred catalyst for the enzymatic synthesis of CMP-Neu5Ac Neisseria meningitidis

Cloned(Commentary)

Cloned (Comment) Organism
the enzyme is subcloned for overexpression in Escherichia coli K12 using the expression vector pKK233-3 Neisseria meningitidis

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + N-acylneuraminate
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Neisseria meningitidis diphosphate + CMP-N-acylneuraminate
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