Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CMP-N-acylneuraminate | - |
[Haemophilus] ducreyi | |
diphosphate | - |
[Haemophilus] ducreyi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0106 | - |
CTP | pH 7.1, 25°C | [Haemophilus] ducreyi | |
0.076 | - |
N-acetylneuraminate | pH 7.1, 25°C | [Haemophilus] ducreyi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
[Haemophilus] ducreyi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate | ordered bi-bi kinetic mechanism. CTP binds first and CMP-NeuAc dissociates last. The rate-limiting step appears to be dissociation of CMP-NeuAc | [Haemophilus] ducreyi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + N-acylneuraminate | - |
[Haemophilus] ducreyi | diphosphate + CMP-N-acylneuraminate | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.8 | - |
CTP | pH 7.1, 25°C | [Haemophilus] ducreyi |