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Literature summary for 2.7.7.41 extracted from

  • Heacock, A.M.; Agranoff, B.W.
    CDP-diacylglycerol synthase from mammalian tissues (1997), Biochim. Biophys. Acta, 1348, 166-172.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
CTP
-
Cavia porcellus
2.5
-
phosphatidate
-
Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome predominantly located in Rattus norvegicus
-
-
mitochondrion 5-10% of the cellular activity Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Escherichia coli
Mg2+
-
Sus scrofa
Mg2+ 50-60 mM required for optimal activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + phosphatidate Cavia porcellus mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Escherichia coli mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Homo sapiens mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Rattus norvegicus mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Sus scrofa mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Rattus norvegicus enzyme plays a central role in phospholipid biosynthesis diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate Drosophila sp. (in: flies) the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate diphosphate + CDPdiacylglycerol
-
?
dCTP + phosphatidate Cavia porcellus mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate Escherichia coli mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate Homo sapiens mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate Rattus norvegicus mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate Sus scrofa mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme diphosphate + dCDPdiacylglycerol
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Drosophila sp. (in: flies)
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
eye
-
Drosophila sp. (in: flies)
-
liver
-
Cavia porcellus
-
liver
-
Rattus norvegicus
-
neuronal cell line
-
Homo sapiens
-
skeletal muscle low activity Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + phosphatidate
-
Cavia porcellus diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate
-
Drosophila sp. (in: flies) diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate
-
Escherichia coli diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate
-
Homo sapiens diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate
-
Rattus norvegicus diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate
-
Sus scrofa diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Cavia porcellus diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Escherichia coli diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Homo sapiens diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Rattus norvegicus diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Sus scrofa diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate enzyme plays a central role in phospholipid biosynthesis Rattus norvegicus diphosphate + CDPdiacylglycerol
-
?
CTP + phosphatidate the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate Drosophila sp. (in: flies) diphosphate + CDPdiacylglycerol
-
?
dCTP + phosphatidate
-
Cavia porcellus diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate
-
Homo sapiens diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate
-
Rattus norvegicus diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate
-
Sus scrofa diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate reaction at the same rate as CTP Escherichia coli diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Cavia porcellus diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Escherichia coli diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Homo sapiens diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Rattus norvegicus diphosphate + dCDPdiacylglycerol
-
?
dCTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme Sus scrofa diphosphate + dCDPdiacylglycerol
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
Rattus norvegicus