Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
CTP | - |
Cavia porcellus | |
2.5 | - |
phosphatidate | - |
Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | predominantly located in | Rattus norvegicus | - |
- |
mitochondrion | 5-10% of the cellular activity | Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli | |
Mg2+ | - |
Sus scrofa | |
Mg2+ | 50-60 mM required for optimal activity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + phosphatidate | Cavia porcellus | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Escherichia coli | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Homo sapiens | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Rattus norvegicus | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Sus scrofa | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Rattus norvegicus | enzyme plays a central role in phospholipid biosynthesis | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | Drosophila sp. (in: flies) | the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate | diphosphate + CDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | Cavia porcellus | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | Escherichia coli | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | Homo sapiens | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | Rattus norvegicus | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | Sus scrofa | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | diphosphate + dCDPdiacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Drosophila sp. (in: flies) | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
eye | - |
Drosophila sp. (in: flies) | - |
liver | - |
Cavia porcellus | - |
liver | - |
Rattus norvegicus | - |
neuronal cell line | - |
Homo sapiens | - |
skeletal muscle | low activity | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + phosphatidate | - |
Cavia porcellus | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | - |
Drosophila sp. (in: flies) | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | - |
Escherichia coli | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | - |
Homo sapiens | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | - |
Rattus norvegicus | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | - |
Sus scrofa | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Cavia porcellus | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Escherichia coli | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Homo sapiens | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Rattus norvegicus | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Sus scrofa | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | enzyme plays a central role in phospholipid biosynthesis | Rattus norvegicus | diphosphate + CDPdiacylglycerol | - |
? | |
CTP + phosphatidate | the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate | Drosophila sp. (in: flies) | diphosphate + CDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | - |
Cavia porcellus | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | - |
Homo sapiens | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | - |
Rattus norvegicus | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | - |
Sus scrofa | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | reaction at the same rate as CTP | Escherichia coli | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Cavia porcellus | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Escherichia coli | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Homo sapiens | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Rattus norvegicus | diphosphate + dCDPdiacylglycerol | - |
? | |
dCTP + phosphatidate | mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme | Sus scrofa | diphosphate + dCDPdiacylglycerol | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
- |
Rattus norvegicus |