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Literature summary for 2.7.7.38 extracted from

  • Nilsson, I.; Grove, K.; Dovala, D.; Uehara, T.; Lapointe, G.; Six, D.A.
    Molecular characterization and verification of azido-3,8-dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide (2017), J. Biol. Chem., 292, 19840-19848 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.38

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
2.6
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Escherichia coli 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 3-deoxy-D-manno-octulosonate Escherichia coli
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P04951
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 3-deoxy-D-manno-octulosonate
-
 Escherichia coli diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 ?
CTP + 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate the enzyme does not efficiently recognize azido-3,8-dideoxy-D-manno-oct-2-ulosonate as a substrate Escherichia coli diphosphate + CMP-azido-3,8-dideoxy-D-manno-oct-2-ulosonate
-
 ?

Synonyms

Synonyms Comment Organism
3-deoxy-D-manno-octulosonate cytidylyltransferase
-
 Escherichia coli
CKS
-
 Escherichia coli
CMP-KDO synthetase
-
 Escherichia coli
Kdo cytidylyltransferase
-
 Escherichia coli
KdsB
-
 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.21
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
1.36
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.5
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
3
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli