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Literature summary for 2.7.7.38 extracted from

  • Tzeng, Y.L.; Datta, A.; Strole, C.; Kolli, V.S.; Birck, M.R.; Taylor, W.P.; Carlson, R.W.; Woodard, R.W.; Stephens, D.S.
    KpsF is the arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression in Neisseria meningitidis (2002), J. Biol. Chem., 277, 24103-24113.
    View publication on PubMed
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Application

Application Comment Organism
medicine exclusive pathogen of humans, cause of epidemic bacterial meningitis and sepsis, potential target for develpoment of antibiotic tools Neisseria meningitidis

Cloned(Commentary)

Cloned (Comment) Organism
KpsF cloned in Escherichia coli DH5alpha, overexpressed in Escherichia coli BLR21(DE3)pLysS Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 3-deoxy-D-manno-octulosonate Neisseria meningitidis
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein, expressed in Escherichia coli Neisseria meningitidis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 3-deoxy-D-manno-octulosonate
-
 Neisseria meningitidis diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r

Synonyms

Synonyms Comment Organism
arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression Neisseria meningitidis
KpsF
-
 Neisseria meningitidis