Crystallization (Comment) | Organism |
---|---|
high-resolution X-ray structures that mimic the pre-catalytic state, the post-catalytic state and a competent state that can be transformed into the two other ones. Zn2+ (or Co2+) in Metal A site changes coordination from octahedral to tetrahedral after the chemical step, which explains the known higher affinity of Tdt for the primer strand when these ions are present, and metal A has to leave to allow the translocation of the primer strand and to clear the active site. Except for Zn2+, the sugar puckering of the primer strand 3' terminus changes from C2'-endo to C3'-endo during catalysis. Metal A is the last component that binds to the active site to complete its productive assembly | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | effect of Mn2+, Co2+ and Zn2+, analysis in X-ray structures that mimic the pre-catalytic state, the post-catalytic state and a competent state | Mus musculus | |
Mn2+ | effect of Mn2+, Co2+ and Zn2+, analysis in X-ray structures that mimic the pre-catalytic state, the post-catalytic state and a competent state | Mus musculus | |
Zn2+ | effect of Mn2+, Co2+ and Zn2+, analysis in X-ray structures that mimic the pre-catalytic state, the post-catalytic state and a competent state | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P09838 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
DNTT | - |
Mus musculus |