Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | exclusively express hTdTS and hTdTl2 | Homo sapiens | - |
lymphoid cell | transformed, hTdTL2 expression is restricted to transformed lymphoid cell lines | Homo sapiens | - |
T-lymphocyte | exclusively express hTdTS and hTdTl2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hTdTL1 | long isoform | Homo sapiens |
hTdTL2 | long isoform | Homo sapiens |
hTdTS | short isoform | Homo sapiens |
terminal deoxynucleotidyltransferase | - |
Homo sapiens |