Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.31 extracted from

  • Thai, T.H.; Kearney, J.F.
    Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants (2004), J. Immunol., 173, 4009-4019.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte exclusively express hTdTS and hTdTl2 Homo sapiens
-
lymphoid cell transformed, hTdTL2 expression is restricted to transformed lymphoid cell lines Homo sapiens
-
T-lymphocyte exclusively express hTdTS and hTdTl2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
hTdTL1 long isoform Homo sapiens
hTdTL2 long isoform Homo sapiens
hTdTS short isoform Homo sapiens
terminal deoxynucleotidyltransferase
-
Homo sapiens