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Literature summary for 2.7.7.31 extracted from

  • Focher, F.; Maga, G.; Bendiscioli, A.; Capobianco, M.; Colonna, F.; Garbesi, A.; Spadari, S.
    Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate (1995), Nucleic Acids Res., 23, 2840-2847.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine mechanism for inhibition of viral proliferation by L-nucleosides Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
L-beta-deoxythymidine-triphosphate i.e. L-dTTP, competitive Bos taurus
L-dTTP
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 D-beta-deoxythymidine-triphosphate pH 6.6, 37°C, primer oligo(dT)20 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-beta-deoxythymidine-triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.06
-
 L-dTTP pH 6.6, 37°C, primer oligo(dT)20 Bos taurus