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Literature summary for 2.7.7.3 extracted from
- Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation (2011), Acta Crystallogr. Sect. F, 67, 541-545.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Mycobacterium tuberculosis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with coenzyme A, hanging drop vapor diffusion method, using 0.1 M Tris base pH 8.0 and 0.15 M magnesium formate | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| coenzyme A | - |
Mycobacterium tuberculosis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantetheine 4'-phosphate | - |
Mycobacterium tuberculosis | diphosphate + 3'-dephospho-CoA | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homohexamer | x-ray crystallography | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphopantetheine adenylyltransferase | - |
Mycobacterium tuberculosis |
| PPAT | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the penultimate step in the coenzyme A biosynthetic pathway | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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