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Literature summary for 2.7.7.27 extracted from

  • Asencion Diez, M.D.; Aleanzi, M.C.; Iglesias, A.A.; Ballicora, M.A.
    A novel dual allosteric activation mechanism of Escherichia coli ADP-glucose pyrophosphorylase: the role of pyruvate (2014), PLoS ONE, 9, e103888.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
pyruvate pyruvate is a weak activator by itself, and synergically enhances the fructose-1,6-bisphosphate activation Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.23
-
 alpha-D-glucose 1-phosphate S0.5 value, Hill coefficient 1.0, presence of 25 mM pyruvate and 0.01 mM fructose 1,6-bisphosphate, pH 8.0, 37°C Escherichia coli
0.57
-
 alpha-D-glucose 1-phosphate S0.5 value, Hill coefficient 1.0, presence of 25 mM pyruvate, pH 8.0, 37°C Escherichia coli
0.77
-
 alpha-D-glucose 1-phosphate S0.5 value, Hill coefficient 1.0, presence of 0.01 mM fructose 1,6-bisphosphate, pH 8.0, 37°C Escherichia coli
0.95
-
 alpha-D-glucose 1-phosphate S0.5 value, Hill coefficient 1.1, pH 8.0, 37°C Escherichia coli
0.99
-
 ATP S0.5 value, Hill coefficient 3.6, presence of 25 mM pyruvate and 0.01 mM fructose 1,6-bisphosphate, pH 8.0, 37°C Escherichia coli
1.67
-
 ATP S0.5 value, Hill coefficient 2.5, presence of 25 mM pyruvate, pH 8.0, 37°C Escherichia coli
5
-
 ATP S0.5 value, Hill coefficient 2.1, presence of 0.01 mM fructose 1,6-bisphosphate, pH 8.0, 37°C Escherichia coli
6.49
-
 ATP S0.5 value, Hill coefficient 1.5, pH 8.0, 37°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha-D-glucose 1-phosphate
-
 Escherichia coli diphosphate + ADP-glucose
-
 ?