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Literature summary for 2.7.7.27 extracted from
- Purification and properties of the adenosine diphosphate-glucose and uridine diphosphate-glucose pyrophosphorylases of Mycobacterium smegmatis: inhibition and activation of the adenosine diphosphate-glucose pyrophosphorylase (1972), J. Bacteriol., 112, 327-336.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| D-fructose 1,6-bisphosphate | - |
Mycolicibacterium smegmatis |  |
| D-fructose 6-phosphate | activation | Mycolicibacterium smegmatis | |
| phosphoenolpyruvate | activation | Mycolicibacterium smegmatis | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | at high concentrations, Mg2+ does not reverse | Mycolicibacterium smegmatis | |
| D-glucose 6-phosphate | - |
Mycolicibacterium smegmatis | |
| additional information | no inhibition by trehalose, trehalose diphosphate, fructose 6-phosphate, ribose 5-phosphate or 3-phosphoglyceraldehyde | Mycolicibacterium smegmatis | |
| phosphate | - |
Mycolicibacterium smegmatis | |
| pyruvate | not | Mycolicibacterium smegmatis | |
| trehalose phosphate | at high concentrations | Mycolicibacterium smegmatis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | - |
ATP | pH 8.0, 37°C | Mycolicibacterium smegmatis | |
| 0.8 | - |
alpha-D-glucose 1-phosphate | pH 8.0, 37°C | Mycolicibacterium smegmatis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Mycolicibacterium smegmatis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycolicibacterium smegmatis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Mycolicibacterium smegmatis |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, partially purified, at least several weeks | Mycolicibacterium smegmatis |
| frozen, partially purified preparation, up to 2 weeks | Mycolicibacterium smegmatis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-D-glucose 1-phosphate | specific for ATP | Mycolicibacterium smegmatis | diphosphate + ADP-glucose | - |
r | |
| ATP + alpha-D-glucose 1-phosphate | no substrate is UTP | Mycolicibacterium smegmatis | diphosphate + ADP-glucose | - |
r | |
| GTP + alpha-D-glucose 1-phosphate | can somewhat replace ATP | Mycolicibacterium smegmatis | diphosphate + GDP-glucose | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Mycolicibacterium smegmatis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 9 | about half-maximal activity at pH 7.2 and about 90% of maximal activity at pH 9.0 | Mycolicibacterium smegmatis |
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