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Literature summary for 2.7.7.27 extracted from

  • Yung, S.G.; Paule, M.; Beggs, R.; Greenberg, E.; Preiss, J.
    Biosynthesis of bacterial glycogen: characterization of adenosine diphosphate glucose synthetases from Enterobacter hafniae and Aeromonas hydrophila (1984), Arch. Microbiol., 138, 1-8.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1,6-Hexanediol bisphosphate activation Salmonella enterica subsp. enterica serovar Typhimurium
1,6-Hexanediol bisphosphate activation Serratia marcescens
1,6-Hexanediol bisphosphate activation Klebsiella pneumoniae
1,6-Hexanediol bisphosphate activation Aeromonas hydrophila
1,6-Hexanediol bisphosphate activation Salmonella enterica subsp. enterica serovar Enteritidis
1,6-Hexanediol bisphosphate activation Hafnia alvei
1,6-Hexanediol bisphosphate activation Shigella dysenteriae
1,6-Hexanediol bisphosphate activation Serratia liquefaciens
1,6-Hexanediol bisphosphate activation Edwardsiella tarda
2-phospho-D-glycerate no activation Salmonella enterica subsp. enterica serovar Typhimurium
2-phospho-D-glycerate no activation Serratia marcescens
2-phospho-D-glycerate no activation Klebsiella pneumoniae
2-phospho-D-glycerate no activation Aeromonas hydrophila
2-phospho-D-glycerate no activation Salmonella enterica subsp. enterica serovar Enteritidis
2-phospho-D-glycerate no activation Hafnia alvei
2-phospho-D-glycerate no activation Shigella dysenteriae
2-phospho-D-glycerate no activation Serratia liquefaciens
2-phospho-D-glycerate no activation Edwardsiella tarda
3-phosphoglycerate activation Salmonella enterica subsp. enterica serovar Typhimurium
3-phosphoglycerate activation Serratia marcescens
3-phosphoglycerate activation Klebsiella pneumoniae
3-phosphoglycerate activation Aeromonas hydrophila
3-phosphoglycerate activation Salmonella enterica subsp. enterica serovar Enteritidis
3-phosphoglycerate activation Hafnia alvei
3-phosphoglycerate activation Shigella dysenteriae
3-phosphoglycerate activation Serratia liquefaciens
3-phosphoglycerate activation Edwardsiella tarda
3-phosphoglycerate no activation Salmonella enterica subsp. enterica serovar Typhimurium
3-phosphoglycerate no activation Serratia marcescens
3-phosphoglycerate no activation Klebsiella pneumoniae
3-phosphoglycerate no activation Aeromonas hydrophila
3-phosphoglycerate no activation Salmonella enterica subsp. enterica serovar Enteritidis
3-phosphoglycerate no activation Hafnia alvei
3-phosphoglycerate no activation Shigella dysenteriae
3-phosphoglycerate no activation Serratia liquefaciens
3-phosphoglycerate no activation Edwardsiella tarda
ADP no activation Salmonella enterica subsp. enterica serovar Typhimurium
ADP no activation Serratia marcescens
ADP no activation Klebsiella pneumoniae
ADP no activation Aeromonas hydrophila
ADP no activation Salmonella enterica subsp. enterica serovar Enteritidis
ADP no activation Hafnia alvei
ADP no activation Shigella dysenteriae
ADP no activation Serratia liquefaciens
ADP no activation Edwardsiella tarda
AMP no activation Salmonella enterica subsp. enterica serovar Typhimurium
AMP no activation Serratia marcescens
AMP no activation Klebsiella pneumoniae
AMP no activation Aeromonas hydrophila
AMP no activation Salmonella enterica subsp. enterica serovar Enteritidis
AMP no activation Hafnia alvei
AMP no activation Shigella dysenteriae
AMP no activation Serratia liquefaciens
AMP no activation Edwardsiella tarda
D-fructose 1,6-bisphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
D-fructose 1,6-bisphosphate
-
Serratia marcescens
D-fructose 1,6-bisphosphate
-
Aeromonas hydrophila
D-fructose 1,6-bisphosphate
-
Hafnia alvei
D-fructose 1,6-bisphosphate
-
Serratia liquefaciens
D-fructose 1,6-bisphosphate one of the most effective activators Klebsiella pneumoniae
D-fructose 1,6-bisphosphate one of the most effective activators Salmonella enterica subsp. enterica serovar Enteritidis
D-fructose 1,6-bisphosphate one of the most effective activators Shigella dysenteriae
D-fructose 1,6-bisphosphate one of the most effective activators Edwardsiella tarda
D-Fructose 1-phosphate activation, less effective than D-fructose 6-phosphate Aeromonas hydrophila
D-fructose 6-phosphate activation Salmonella enterica subsp. enterica serovar Typhimurium
D-fructose 6-phosphate activation Serratia marcescens
D-fructose 6-phosphate activation Klebsiella pneumoniae
D-fructose 6-phosphate activation Aeromonas hydrophila
D-fructose 6-phosphate activation Salmonella enterica subsp. enterica serovar Enteritidis
D-fructose 6-phosphate activation Hafnia alvei
D-fructose 6-phosphate activation Shigella dysenteriae
D-fructose 6-phosphate activation Serratia liquefaciens
D-fructose 6-phosphate activation Edwardsiella tarda
D-fructose 6-phosphate no activation Serratia marcescens
D-fructose 6-phosphate no activation Hafnia alvei
D-fructose 6-phosphate no activation Serratia liquefaciens
D-fructose 6-phosphate most effective allosteric activator of aeromonad enzyme Aeromonas hydrophila
D-glucose 6-phosphate no activation Salmonella enterica subsp. enterica serovar Typhimurium
D-glucose 6-phosphate no activation Serratia marcescens
D-glucose 6-phosphate no activation Klebsiella pneumoniae
D-glucose 6-phosphate no activation Aeromonas hydrophila
D-glucose 6-phosphate no activation Salmonella enterica subsp. enterica serovar Enteritidis
D-glucose 6-phosphate no activation Hafnia alvei
D-glucose 6-phosphate no activation Edwardsiella tarda
D-mannose 6-phosphate activation, less effective than D-fructose 6-phosphate Aeromonas hydrophila
dihydroxyacetone phosphate no activation Salmonella enterica subsp. enterica serovar Typhimurium
dihydroxyacetone phosphate no activation Serratia marcescens
dihydroxyacetone phosphate no activation Klebsiella pneumoniae
dihydroxyacetone phosphate no activation Aeromonas hydrophila
dihydroxyacetone phosphate no activation Salmonella enterica subsp. enterica serovar Enteritidis
dihydroxyacetone phosphate no activation Hafnia alvei
dihydroxyacetone phosphate no activation Shigella dysenteriae
dihydroxyacetone phosphate no activation Serratia liquefaciens
dihydroxyacetone phosphate no activation Edwardsiella tarda
additional information
-
Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
Serratia marcescens
additional information
-
Klebsiella pneumoniae
additional information
-
Salmonella enterica subsp. enterica serovar Enteritidis
additional information
-
Shigella dysenteriae
additional information
-
Serratia liquefaciens
additional information
-
Edwardsiella tarda
additional information no activation of Enterobacter hafniae or Aeromonas hydrophila enzyme by NADH, pyruvate, NAD+, NADP+, phosphate, erythrose 4-phosphate, malate, cAMP Aeromonas hydrophila
additional information no activation of Enterobacter hafniae or Aeromonas hydrophila enzyme by NADH, pyruvate, NAD+, NADP+, phosphate, erythrose 4-phosphate, malate, cAMP Hafnia alvei
NADPH activation Salmonella enterica subsp. enterica serovar Typhimurium
NADPH activation Serratia marcescens
NADPH activation Klebsiella pneumoniae
NADPH activation Aeromonas hydrophila
NADPH activation Salmonella enterica subsp. enterica serovar Enteritidis
NADPH activation Hafnia alvei
NADPH activation Shigella dysenteriae
NADPH activation Serratia liquefaciens
NADPH activation Edwardsiella tarda
NADPH no activation Aeromonas hydrophila
NADPH no activation Hafnia alvei
NADPH one of the most effective activators Klebsiella pneumoniae
NADPH one of the most effective activators Salmonella enterica subsp. enterica serovar Enteritidis
NADPH one of the most effective activators Shigella dysenteriae
NADPH one of the most effective activators Edwardsiella tarda
phosphoenolpyruvate activation Salmonella enterica subsp. enterica serovar Typhimurium
phosphoenolpyruvate activation Serratia marcescens
phosphoenolpyruvate activation Klebsiella pneumoniae
phosphoenolpyruvate activation Aeromonas hydrophila
phosphoenolpyruvate activation Salmonella enterica subsp. enterica serovar Enteritidis
phosphoenolpyruvate activation Hafnia alvei
phosphoenolpyruvate activation Shigella dysenteriae
phosphoenolpyruvate activation Serratia liquefaciens
phosphoenolpyruvate activation Edwardsiella tarda
phosphoenolpyruvate most effective for Enterobacter hafniae Hafnia alvei
pyridoxal 5'-phosphate activation Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate activation Serratia marcescens
pyridoxal 5'-phosphate activation Klebsiella pneumoniae
pyridoxal 5'-phosphate activation Aeromonas hydrophila
pyridoxal 5'-phosphate activation Salmonella enterica subsp. enterica serovar Enteritidis
pyridoxal 5'-phosphate activation Hafnia alvei
pyridoxal 5'-phosphate activation Shigella dysenteriae
pyridoxal 5'-phosphate activation Serratia liquefaciens
pyridoxal 5'-phosphate activation Edwardsiella tarda
pyridoxal 5'-phosphate one of the most effective activators, less effective for Enterobacter hafniae Klebsiella pneumoniae
pyridoxal 5'-phosphate one of the most effective activators, less effective for Enterobacter hafniae Salmonella enterica subsp. enterica serovar Enteritidis
pyridoxal 5'-phosphate one of the most effective activators, less effective for Enterobacter hafniae Hafnia alvei
pyridoxal 5'-phosphate one of the most effective activators, less effective for Enterobacter hafniae Shigella dysenteriae
pyridoxal 5'-phosphate one of the most effective activators, less effective for Enterobacter hafniae Edwardsiella tarda
sedoheptulose 1,7-diphosphate activation Salmonella enterica subsp. enterica serovar Typhimurium
sedoheptulose 1,7-diphosphate activation Serratia marcescens
sedoheptulose 1,7-diphosphate activation Klebsiella pneumoniae
sedoheptulose 1,7-diphosphate activation Aeromonas hydrophila
sedoheptulose 1,7-diphosphate activation Salmonella enterica subsp. enterica serovar Enteritidis
sedoheptulose 1,7-diphosphate activation Hafnia alvei
sedoheptulose 1,7-diphosphate activation Shigella dysenteriae
sedoheptulose 1,7-diphosphate activation Serratia liquefaciens
sedoheptulose 1,7-diphosphate activation Edwardsiella tarda

Inhibitors

Inhibitors Comment Organism Structure
ADP most effective, fructose 6-phosphate or fructose 1,6-bisphosphate partially reverses Aeromonas hydrophila
ADP
-
Edwardsiella tarda
ADP phosphoenolpyruvate reverses Hafnia alvei
ADP
-
Klebsiella pneumoniae
ADP
-
Salmonella enterica subsp. enterica serovar Enteritidis
ADP
-
Salmonella enterica subsp. enterica serovar Typhimurium
ADP
-
Serratia liquefaciens
ADP
-
Serratia marcescens
ADP
-
Shigella dysenteriae
AMP not Aeromonas hydrophila
AMP
-
Edwardsiella tarda
AMP strong, phosphoenolpyruvate partially reverses Hafnia alvei
AMP
-
Klebsiella pneumoniae
AMP
-
Salmonella enterica subsp. enterica serovar Enteritidis
AMP
-
Salmonella enterica subsp. enterica serovar Typhimurium
AMP
-
Serratia liquefaciens
AMP
-
Serratia marcescens
AMP
-
Shigella dysenteriae
phosphate
-
Aeromonas hydrophila
phosphate
-
Edwardsiella tarda
phosphate not Hafnia alvei
phosphate
-
Klebsiella pneumoniae
phosphate
-
Salmonella enterica subsp. enterica serovar Enteritidis
phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
phosphate
-
Serratia liquefaciens
phosphate
-
Serratia marcescens
phosphate
-
Shigella dysenteriae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information the allosteric properties of Enterobacter hafniae are distinctly different from other bacteria of the genus Enterobacter Hafnia alvei
additional information
-
additional information the allosteric properties of Enterobacter hafniae are distinctly different from other bacteria of the genus Enterobacter Edwardsiella tarda
0.026
-
alpha-D-glucose 1-phosphate pH 8.0, 37°C Hafnia alvei
0.15
-
ATP pH 8.0, 37°C Aeromonas hydrophila
0.36
-
ATP pH 8.0, 37°C Hafnia alvei
30
-
alpha-D-glucose 1-phosphate pH 8.0, 37°C Aeromonas hydrophila

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
sucrose density gradient method Aeromonas hydrophila
200000
-
sucrose density gradient method Hafnia alvei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + alpha-D-glucose 1-phosphate Salmonella enterica subsp. enterica serovar Typhimurium major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Serratia marcescens major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Klebsiella pneumoniae major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Aeromonas hydrophila major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Salmonella enterica subsp. enterica serovar Enteritidis major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Hafnia alvei major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Shigella dysenteriae major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Serratia liquefaciens major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate Edwardsiella tarda major regulated step in the bacterial glycogen biosynthesis pathway diphosphate + ADP-glucose
-
r

Organism

Organism UniProt Comment Textmining
Aeromonas hydrophila
-
-
-
Edwardsiella tarda
-
-
-
Hafnia alvei
-
-
-
Klebsiella pneumoniae
-
-
-
Salmonella enterica subsp. enterica serovar Enteritidis
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Serratia liquefaciens
-
-
-
Serratia marcescens
-
-
-
Shigella dysenteriae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Aeromonas hydrophila
partial Hafnia alvei

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5
-
-
Hafnia alvei
28.2
-
-
Aeromonas hydrophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha-D-glucose 1-phosphate specific for ATP Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Serratia marcescens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Klebsiella pneumoniae diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Aeromonas hydrophila diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Salmonella enterica subsp. enterica serovar Enteritidis diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Hafnia alvei diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Shigella dysenteriae diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Serratia liquefaciens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate specific for ATP Edwardsiella tarda diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: ITP Serratia marcescens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: ITP Aeromonas hydrophila diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: ITP Hafnia alvei diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate no substrate are GTP, dATP, CTP Serratia marcescens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate no substrate are GTP, dATP, CTP Aeromonas hydrophila diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate no substrate are GTP, dATP, CTP Hafnia alvei diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: dTTP, XTP Serratia marcescens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: dTTP, XTP Aeromonas hydrophila diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate not: dTTP, XTP Hafnia alvei diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Serratia marcescens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Klebsiella pneumoniae diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Aeromonas hydrophila diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Salmonella enterica subsp. enterica serovar Enteritidis diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Hafnia alvei diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Shigella dysenteriae diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Serratia liquefaciens diphosphate + ADP-glucose
-
r
ATP + alpha-D-glucose 1-phosphate major regulated step in the bacterial glycogen biosynthesis pathway Edwardsiella tarda diphosphate + ADP-glucose
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
ADP-glucose synthesis, HEPES buffer Aeromonas hydrophila
8
-
-
Serratia marcescens
8
-
ADP-glucose synthesis Hafnia alvei
8
-
bicine buffer Aeromonas hydrophila

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
AMP pH 8.0, 37°C, in absence of phosphoenolpyruvate Hafnia alvei
0.023
-
AMP pH 8.0, 37°C, in presence of phosphoenolpyruvate Hafnia alvei
0.104
-
ADP pH 8.0, 37°C, in absence of phosphoenolpyruvate Hafnia alvei
0.204
-
AMP pH 8.0, 37°C, in presence of phosphoenolpyruvate Hafnia alvei
1.7
-
ADP pH 8.0, 37°C, in presence of fructose 1,6-bisphosphate Aeromonas hydrophila
2
-
ADP pH 8.0, 37°C, in presence of fructose 6-phosphate Aeromonas hydrophila
2.9
-
ADP pH 8.0, 37°C Aeromonas hydrophila