Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,6-Hexanediol bisphosphate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
1,6-Hexanediol bisphosphate | activation | Serratia marcescens | |
1,6-Hexanediol bisphosphate | activation | Klebsiella pneumoniae | |
1,6-Hexanediol bisphosphate | activation | Aeromonas hydrophila | |
1,6-Hexanediol bisphosphate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
1,6-Hexanediol bisphosphate | activation | Hafnia alvei | |
1,6-Hexanediol bisphosphate | activation | Shigella dysenteriae | |
1,6-Hexanediol bisphosphate | activation | Serratia liquefaciens | |
1,6-Hexanediol bisphosphate | activation | Edwardsiella tarda | |
2-phospho-D-glycerate | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
2-phospho-D-glycerate | no activation | Serratia marcescens | |
2-phospho-D-glycerate | no activation | Klebsiella pneumoniae | |
2-phospho-D-glycerate | no activation | Aeromonas hydrophila | |
2-phospho-D-glycerate | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
2-phospho-D-glycerate | no activation | Hafnia alvei | |
2-phospho-D-glycerate | no activation | Shigella dysenteriae | |
2-phospho-D-glycerate | no activation | Serratia liquefaciens | |
2-phospho-D-glycerate | no activation | Edwardsiella tarda | |
3-phosphoglycerate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
3-phosphoglycerate | activation | Serratia marcescens | |
3-phosphoglycerate | activation | Klebsiella pneumoniae | |
3-phosphoglycerate | activation | Aeromonas hydrophila | |
3-phosphoglycerate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
3-phosphoglycerate | activation | Hafnia alvei | |
3-phosphoglycerate | activation | Shigella dysenteriae | |
3-phosphoglycerate | activation | Serratia liquefaciens | |
3-phosphoglycerate | activation | Edwardsiella tarda | |
3-phosphoglycerate | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
3-phosphoglycerate | no activation | Serratia marcescens | |
3-phosphoglycerate | no activation | Klebsiella pneumoniae | |
3-phosphoglycerate | no activation | Aeromonas hydrophila | |
3-phosphoglycerate | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
3-phosphoglycerate | no activation | Hafnia alvei | |
3-phosphoglycerate | no activation | Shigella dysenteriae | |
3-phosphoglycerate | no activation | Serratia liquefaciens | |
3-phosphoglycerate | no activation | Edwardsiella tarda | |
ADP | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
ADP | no activation | Serratia marcescens | |
ADP | no activation | Klebsiella pneumoniae | |
ADP | no activation | Aeromonas hydrophila | |
ADP | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
ADP | no activation | Hafnia alvei | |
ADP | no activation | Shigella dysenteriae | |
ADP | no activation | Serratia liquefaciens | |
ADP | no activation | Edwardsiella tarda | |
AMP | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
AMP | no activation | Serratia marcescens | |
AMP | no activation | Klebsiella pneumoniae | |
AMP | no activation | Aeromonas hydrophila | |
AMP | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
AMP | no activation | Hafnia alvei | |
AMP | no activation | Shigella dysenteriae | |
AMP | no activation | Serratia liquefaciens | |
AMP | no activation | Edwardsiella tarda | |
D-fructose 1,6-bisphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
D-fructose 1,6-bisphosphate | - |
Serratia marcescens | |
D-fructose 1,6-bisphosphate | - |
Aeromonas hydrophila | |
D-fructose 1,6-bisphosphate | - |
Hafnia alvei | |
D-fructose 1,6-bisphosphate | - |
Serratia liquefaciens | |
D-fructose 1,6-bisphosphate | one of the most effective activators | Klebsiella pneumoniae | |
D-fructose 1,6-bisphosphate | one of the most effective activators | Salmonella enterica subsp. enterica serovar Enteritidis | |
D-fructose 1,6-bisphosphate | one of the most effective activators | Shigella dysenteriae | |
D-fructose 1,6-bisphosphate | one of the most effective activators | Edwardsiella tarda | |
D-Fructose 1-phosphate | activation, less effective than D-fructose 6-phosphate | Aeromonas hydrophila | |
D-fructose 6-phosphate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
D-fructose 6-phosphate | activation | Serratia marcescens | |
D-fructose 6-phosphate | activation | Klebsiella pneumoniae | |
D-fructose 6-phosphate | activation | Aeromonas hydrophila | |
D-fructose 6-phosphate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
D-fructose 6-phosphate | activation | Hafnia alvei | |
D-fructose 6-phosphate | activation | Shigella dysenteriae | |
D-fructose 6-phosphate | activation | Serratia liquefaciens | |
D-fructose 6-phosphate | activation | Edwardsiella tarda | |
D-fructose 6-phosphate | no activation | Serratia marcescens | |
D-fructose 6-phosphate | no activation | Hafnia alvei | |
D-fructose 6-phosphate | no activation | Serratia liquefaciens | |
D-fructose 6-phosphate | most effective allosteric activator of aeromonad enzyme | Aeromonas hydrophila | |
D-glucose 6-phosphate | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
D-glucose 6-phosphate | no activation | Serratia marcescens | |
D-glucose 6-phosphate | no activation | Klebsiella pneumoniae | |
D-glucose 6-phosphate | no activation | Aeromonas hydrophila | |
D-glucose 6-phosphate | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
D-glucose 6-phosphate | no activation | Hafnia alvei | |
D-glucose 6-phosphate | no activation | Edwardsiella tarda | |
D-mannose 6-phosphate | activation, less effective than D-fructose 6-phosphate | Aeromonas hydrophila | |
dihydroxyacetone phosphate | no activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
dihydroxyacetone phosphate | no activation | Serratia marcescens | |
dihydroxyacetone phosphate | no activation | Klebsiella pneumoniae | |
dihydroxyacetone phosphate | no activation | Aeromonas hydrophila | |
dihydroxyacetone phosphate | no activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
dihydroxyacetone phosphate | no activation | Hafnia alvei | |
dihydroxyacetone phosphate | no activation | Shigella dysenteriae | |
dihydroxyacetone phosphate | no activation | Serratia liquefaciens | |
dihydroxyacetone phosphate | no activation | Edwardsiella tarda | |
additional information | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | - |
Serratia marcescens | |
additional information | - |
Klebsiella pneumoniae | |
additional information | - |
Salmonella enterica subsp. enterica serovar Enteritidis | |
additional information | - |
Shigella dysenteriae | |
additional information | - |
Serratia liquefaciens | |
additional information | - |
Edwardsiella tarda | |
additional information | no activation of Enterobacter hafniae or Aeromonas hydrophila enzyme by NADH, pyruvate, NAD+, NADP+, phosphate, erythrose 4-phosphate, malate, cAMP | Aeromonas hydrophila | |
additional information | no activation of Enterobacter hafniae or Aeromonas hydrophila enzyme by NADH, pyruvate, NAD+, NADP+, phosphate, erythrose 4-phosphate, malate, cAMP | Hafnia alvei | |
NADPH | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
NADPH | activation | Serratia marcescens | |
NADPH | activation | Klebsiella pneumoniae | |
NADPH | activation | Aeromonas hydrophila | |
NADPH | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
NADPH | activation | Hafnia alvei | |
NADPH | activation | Shigella dysenteriae | |
NADPH | activation | Serratia liquefaciens | |
NADPH | activation | Edwardsiella tarda | |
NADPH | no activation | Aeromonas hydrophila | |
NADPH | no activation | Hafnia alvei | |
NADPH | one of the most effective activators | Klebsiella pneumoniae | |
NADPH | one of the most effective activators | Salmonella enterica subsp. enterica serovar Enteritidis | |
NADPH | one of the most effective activators | Shigella dysenteriae | |
NADPH | one of the most effective activators | Edwardsiella tarda | |
phosphoenolpyruvate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
phosphoenolpyruvate | activation | Serratia marcescens | |
phosphoenolpyruvate | activation | Klebsiella pneumoniae | |
phosphoenolpyruvate | activation | Aeromonas hydrophila | |
phosphoenolpyruvate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
phosphoenolpyruvate | activation | Hafnia alvei | |
phosphoenolpyruvate | activation | Shigella dysenteriae | |
phosphoenolpyruvate | activation | Serratia liquefaciens | |
phosphoenolpyruvate | activation | Edwardsiella tarda | |
phosphoenolpyruvate | most effective for Enterobacter hafniae | Hafnia alvei | |
pyridoxal 5'-phosphate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
pyridoxal 5'-phosphate | activation | Serratia marcescens | |
pyridoxal 5'-phosphate | activation | Klebsiella pneumoniae | |
pyridoxal 5'-phosphate | activation | Aeromonas hydrophila | |
pyridoxal 5'-phosphate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
pyridoxal 5'-phosphate | activation | Hafnia alvei | |
pyridoxal 5'-phosphate | activation | Shigella dysenteriae | |
pyridoxal 5'-phosphate | activation | Serratia liquefaciens | |
pyridoxal 5'-phosphate | activation | Edwardsiella tarda | |
pyridoxal 5'-phosphate | one of the most effective activators, less effective for Enterobacter hafniae | Klebsiella pneumoniae | |
pyridoxal 5'-phosphate | one of the most effective activators, less effective for Enterobacter hafniae | Salmonella enterica subsp. enterica serovar Enteritidis | |
pyridoxal 5'-phosphate | one of the most effective activators, less effective for Enterobacter hafniae | Hafnia alvei | |
pyridoxal 5'-phosphate | one of the most effective activators, less effective for Enterobacter hafniae | Shigella dysenteriae | |
pyridoxal 5'-phosphate | one of the most effective activators, less effective for Enterobacter hafniae | Edwardsiella tarda | |
sedoheptulose 1,7-diphosphate | activation | Salmonella enterica subsp. enterica serovar Typhimurium | |
sedoheptulose 1,7-diphosphate | activation | Serratia marcescens | |
sedoheptulose 1,7-diphosphate | activation | Klebsiella pneumoniae | |
sedoheptulose 1,7-diphosphate | activation | Aeromonas hydrophila | |
sedoheptulose 1,7-diphosphate | activation | Salmonella enterica subsp. enterica serovar Enteritidis | |
sedoheptulose 1,7-diphosphate | activation | Hafnia alvei | |
sedoheptulose 1,7-diphosphate | activation | Shigella dysenteriae | |
sedoheptulose 1,7-diphosphate | activation | Serratia liquefaciens | |
sedoheptulose 1,7-diphosphate | activation | Edwardsiella tarda |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | most effective, fructose 6-phosphate or fructose 1,6-bisphosphate partially reverses | Aeromonas hydrophila | |
ADP | - |
Edwardsiella tarda | |
ADP | phosphoenolpyruvate reverses | Hafnia alvei | |
ADP | - |
Klebsiella pneumoniae | |
ADP | - |
Salmonella enterica subsp. enterica serovar Enteritidis | |
ADP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
ADP | - |
Serratia liquefaciens | |
ADP | - |
Serratia marcescens | |
ADP | - |
Shigella dysenteriae | |
AMP | not | Aeromonas hydrophila | |
AMP | - |
Edwardsiella tarda | |
AMP | strong, phosphoenolpyruvate partially reverses | Hafnia alvei | |
AMP | - |
Klebsiella pneumoniae | |
AMP | - |
Salmonella enterica subsp. enterica serovar Enteritidis | |
AMP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
AMP | - |
Serratia liquefaciens | |
AMP | - |
Serratia marcescens | |
AMP | - |
Shigella dysenteriae | |
phosphate | - |
Aeromonas hydrophila | |
phosphate | - |
Edwardsiella tarda | |
phosphate | not | Hafnia alvei | |
phosphate | - |
Klebsiella pneumoniae | |
phosphate | - |
Salmonella enterica subsp. enterica serovar Enteritidis | |
phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
phosphate | - |
Serratia liquefaciens | |
phosphate | - |
Serratia marcescens | |
phosphate | - |
Shigella dysenteriae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the allosteric properties of Enterobacter hafniae are distinctly different from other bacteria of the genus Enterobacter | Hafnia alvei | |
additional information | - |
additional information | the allosteric properties of Enterobacter hafniae are distinctly different from other bacteria of the genus Enterobacter | Edwardsiella tarda | |
0.026 | - |
alpha-D-glucose 1-phosphate | pH 8.0, 37°C | Hafnia alvei | |
0.15 | - |
ATP | pH 8.0, 37°C | Aeromonas hydrophila | |
0.36 | - |
ATP | pH 8.0, 37°C | Hafnia alvei | |
30 | - |
alpha-D-glucose 1-phosphate | pH 8.0, 37°C | Aeromonas hydrophila |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
200000 | - |
sucrose density gradient method | Aeromonas hydrophila |
200000 | - |
sucrose density gradient method | Hafnia alvei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha-D-glucose 1-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Serratia marcescens | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Klebsiella pneumoniae | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Aeromonas hydrophila | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Salmonella enterica subsp. enterica serovar Enteritidis | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Hafnia alvei | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Shigella dysenteriae | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Serratia liquefaciens | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | Edwardsiella tarda | major regulated step in the bacterial glycogen biosynthesis pathway | diphosphate + ADP-glucose | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aeromonas hydrophila | - |
- |
- |
Edwardsiella tarda | - |
- |
- |
Hafnia alvei | - |
- |
- |
Klebsiella pneumoniae | - |
- |
- |
Salmonella enterica subsp. enterica serovar Enteritidis | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Serratia liquefaciens | - |
- |
- |
Serratia marcescens | - |
- |
- |
Shigella dysenteriae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Aeromonas hydrophila |
partial | Hafnia alvei |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.5 | - |
- |
Hafnia alvei |
28.2 | - |
- |
Aeromonas hydrophila |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Salmonella enterica subsp. enterica serovar Typhimurium | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Serratia marcescens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Klebsiella pneumoniae | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Aeromonas hydrophila | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Salmonella enterica subsp. enterica serovar Enteritidis | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Hafnia alvei | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Shigella dysenteriae | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Serratia liquefaciens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | specific for ATP | Edwardsiella tarda | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: ITP | Serratia marcescens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: ITP | Aeromonas hydrophila | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: ITP | Hafnia alvei | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | no substrate are GTP, dATP, CTP | Serratia marcescens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | no substrate are GTP, dATP, CTP | Aeromonas hydrophila | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | no substrate are GTP, dATP, CTP | Hafnia alvei | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: dTTP, XTP | Serratia marcescens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: dTTP, XTP | Aeromonas hydrophila | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | not: dTTP, XTP | Hafnia alvei | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Salmonella enterica subsp. enterica serovar Typhimurium | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Serratia marcescens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Klebsiella pneumoniae | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Aeromonas hydrophila | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Salmonella enterica subsp. enterica serovar Enteritidis | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Hafnia alvei | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Shigella dysenteriae | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Serratia liquefaciens | diphosphate + ADP-glucose | - |
r | |
ATP + alpha-D-glucose 1-phosphate | major regulated step in the bacterial glycogen biosynthesis pathway | Edwardsiella tarda | diphosphate + ADP-glucose | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
ADP-glucose synthesis, HEPES buffer | Aeromonas hydrophila |
8 | - |
- |
Serratia marcescens |
8 | - |
ADP-glucose synthesis | Hafnia alvei |
8 | - |
bicine buffer | Aeromonas hydrophila |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
AMP | pH 8.0, 37°C, in absence of phosphoenolpyruvate | Hafnia alvei | |
0.023 | - |
AMP | pH 8.0, 37°C, in presence of phosphoenolpyruvate | Hafnia alvei | |
0.104 | - |
ADP | pH 8.0, 37°C, in absence of phosphoenolpyruvate | Hafnia alvei | |
0.204 | - |
AMP | pH 8.0, 37°C, in presence of phosphoenolpyruvate | Hafnia alvei | |
1.7 | - |
ADP | pH 8.0, 37°C, in presence of fructose 1,6-bisphosphate | Aeromonas hydrophila | |
2 | - |
ADP | pH 8.0, 37°C, in presence of fructose 6-phosphate | Aeromonas hydrophila | |
2.9 | - |
ADP | pH 8.0, 37°C | Aeromonas hydrophila |