Literature summary for 2.7.7.24 extracted from

Smithen, D.A.; Forget, S.M.; McCormick, N.E.; Syvitski, R.T.; Jakeman, D.L.
Polyphosphate-containing bisubstrate analogues as inhibitors of a bacterial cell wall thymidylyltransferase (2015), Org. Biomol. Chem., 13, 3347-3350.

Search for more literature for 2.7.7.24

Inhibitors

Inhibitors	Comment	Organism	Structure
deoxythymidine 5'-tetraphosphate	bisubstrate inhibitor with increased length of polyphosphate linker, competitve inhibition	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTTP + alpha-D-glucose 1-phosphate	-	Streptococcus pneumoniae	diphosphate + dTDP-alpha-D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
Cps2L	-	Streptococcus pneumoniae

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.085	-	deoxythymidine 5'-tetraphosphate	pH 7.5, temperature not specified in the publication	Streptococcus pneumoniae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)