Application | Comment | Organism |
---|---|---|
drug development | N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is an attractive target for the development of antimicrobial agents | Xanthomonas oryzae pv. oryzae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | for development of potent and selective inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU, three types of target compounds are optimized and synthesized based on the Xo-GlmU structure, docking stud, and biological activity evaluation, overview | Xanthomonas oryzae pv. oryzae | |
N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | - |
Xanthomonas oryzae pv. oryzae | |
N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide | - |
Xanthomonas oryzae pv. oryzae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Xanthomonas oryzae pv. oryzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | Xanthomonas oryzae pv. oryzae | - |
diphosphate + UDP-N-acetyl-alpha-D-glucosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xanthomonas oryzae pv. oryzae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
Xanthomonas oryzae pv. oryzae | diphosphate + UDP-N-acetyl-alpha-D-glucosamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GlmU | - |
Xanthomonas oryzae pv. oryzae |
N-acetylglucosamine-1-phosphate uridyltransferase | - |
Xanthomonas oryzae pv. oryzae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Xanthomonas oryzae pv. oryzae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Xanthomonas oryzae pv. oryzae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0108 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | |
0.0112 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | |
0.0125 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | |
0.0134 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | |
0.0138 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide | |
0.0154 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | |
0.0171 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide | |
0.0184 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide | |
0.0194 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide | |
0.022 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | |
0.0233 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide | |
0.0332 | - |
pH 7.5, 37°C | Xanthomonas oryzae pv. oryzae | N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide |