BRENDA - Enzyme Database
show all sequences of 2.7.7.23

Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) inhibitory activity of terreic acid isolated from Aspergillus terreus

Sharma, R.; Lambu, M.R.; Jamwal, U.; Rani, C.; Chib, R.; Wazir, P.; Mukherjee, D.; Chaubey, A.; Khan, I.A.; J. Biomol. Screen. 21, 342-353 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene glmU, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
Escherichia coli
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition with terreic acid, isolated from Aspergillus terreus, the compound inhibits the acetyltransferase activity of Escherichia coli GlmU but not the uridinyltransferase activity
Escherichia coli
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Escherichia coli
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
Escherichia coli
-
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
Escherichia coli ATCC 25922
-
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
P0ACC7
Escherichia coli K-12
-
Escherichia coli ATCC 25922
P0ACC7
Escherichia coli K-12
-
Purification (Commentary)
Commentary
Organism
recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
736517
Escherichia coli
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
-
?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
736517
Escherichia coli ATCC 25922
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Escherichia coli
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
65
-
inactivation
Escherichia coli
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Escherichia coli
Cloned(Commentary) (protein specific)
Commentary
Organism
gene glmU, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition with terreic acid, isolated from Aspergillus terreus, the compound inhibits the acetyltransferase activity of Escherichia coli GlmU but not the uridinyltransferase activity
Escherichia coli
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
Escherichia coli
-
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
Escherichia coli ATCC 25922
-
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
736517
Escherichia coli
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
-
?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
736517
Escherichia coli ATCC 25922
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Escherichia coli
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
65
-
inactivation
Escherichia coli
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Escherichia coli
Other publictions for EC 2.7.7.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746844
Honda
Improvement of ST0452 N-acety ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993
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84
e002213-18
2018
-
-
1
1
2
-
-
-
-
-
-
-
-
10
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1
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1
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1
2
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
748113
Dadashipour
Identification of a direct bi ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993
J. Bacteriol.
200
e00048-18
2018
-
-
-
-
-
-
-
-
-
-
-
2
-
8
-
-
-
-
-
-
-
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4
-
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2
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-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
746841
Honda
Increasing the thermostable s ...
Escherichia coli, Escherichia coli K12, Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993
Appl. Environ. Microbiol.
83
e02291
2017
-
-
-
-
15
-
-
4
-
-
-
-
-
12
-
-
2
-
-
-
-
-
4
-
2
-
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4
2
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
4
-
-
-
-
-
-
-
2
-
-
-
-
4
-
2
-
-
4
2
-
-
-
-
-
-
-
4
4
736517
Sharma
Escherichia coli N-acetylgluco ...
Escherichia coli, Escherichia coli ATCC 25922
J. Biomol. Screen.
21
342-353
2016
-
-
1
-
-
-
1
-
-
1
-
2
-
4
-
-
1
-
-
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
737096
Dziadek
Mycobacterium tuberculosis Ats ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
11
e0148030
2016
-
-
1
-
1
-
-
-
-
-
-
3
-
9
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738383
Shi
Two Leptinotarsa uridine dipho ...
Leptinotarsa decemlineata
Insect Biochem. Mol. Biol.
68
1-12
2016
-
-
1
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
12
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
24
-
-
2
-
-
-
-
-
-
-
-
-
2
2
4
4
-
-
729696
Zhang
Characterization of the amino ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7
Extremophiles
19
417-427
2015
-
-
1
-
6
-
-
-
-
1
-
3
-
4
-
-
-
-
-
-
3
-
6
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
3
-
6
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
735518
Sharma
Identification and characteriz ...
Escherichia coli, Escherichia coli ATCC 25922
Appl. Microbiol. Biotechnol.
100
3071-3085
2015
-
-
1
-
-
-
-
-
-
1
-
4
-
4
-
-
1
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
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-
1
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-
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-
-
-
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-
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1
-
4
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-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
735569
Patin
Purification and biochemical c ...
Yersinia pseudotuberculosis, Yersinia pseudotuberculosis YPIII
Arch. Microbiol.
197
371-378
2015
-
-
1
-
1
-
-
2
-
1
-
2
-
2
-
-
1
-
-
-
-
-
2
2
1
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
2
-
1
-
2
-
-
-
1
-
-
-
-
2
2
1
-
-
2
1
-
-
-
-
2
2
-
-
-
737150
Soni
Depletion of M. tuberculosis G ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS Pathog.
11
e1005235
2015
-
1
1
-
-
-
1
-
-
-
-
6
-
13
-
-
-
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
1
-
1
1
-
-
-
-
1
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
737291
Rani
High-throughput screen identif ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Tuberculosis
95
664-677
2015
-
-
1
-
-
-
2
3
-
1
-
4
-
9
-
-
1
-
-
-
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
2
-
3
-
1
-
4
-
-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
737391
Edwards
Structure of uridine diphospha ...
Entamoeba histolytica
Acta Crystallogr. Sect. F
71
560-565
2015
-
1
1
1
-
-
-
-
-
-
-
2
-
2
-
-
1
-
-
-
-
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2
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2
2
-
2
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2
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
6
-
-
-
738765
Wang
Functional inactivation of UDP ...
Oryza sativa Japonica Group, Oryza sativa Japonica Group ZH11
J. Exp. Bot.
66
973-987
2015
-
-
1
-
1
-
-
-
-
-
-
4
-
4
-
-
-
-
-
3
-
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4
1
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-
1
-
-
1
-
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4
-
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-
-
3
-
-
4
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
740262
Wang
Probing the roles of conserved ...
Escherichia coli
Carbohydr. Res.
413
70-74
2015
-
-
1
-
15
-
-
-
-
1
-
1
-
1
-
-
-
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-
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3
-
1
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-
1
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1
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-
15
-
-
-
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-
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1
-
1
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-
-
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-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
3
3
-
-
-
741100
Qi
Novel lead compound optimizati ...
Xanthomonas oryzae pv. oryzae
Pestic. Biochem. Physiol.
122
22-28
2015
-
1
-
-
-
-
13
-
-
1
-
1
-
1
-
-
-
-
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1
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1
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1
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12
-
1
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12
13
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1
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1
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1
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1
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1
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-
-
-
-
-
735396
Vithani
GlmU (N-acetylglucosamine-1-ph ...
Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
70
703-708
2014
-
-
-
1
-
-
2
-
-
1
-
1
-
1
-
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-
-
-
-
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2
-
1
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1
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1
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2
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1
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1
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2
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1
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1
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2
2
-
-
-
722022
Santos Junior
Structure-based drug design st ...
Moniliophthora perniciosa
Chem. Cent. J.
7
48
2013
-
1
-
1
-
-
13
-
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1
-
4
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-
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-
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2
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1
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1
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13
-
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1
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2
-
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-
-
2
2
-
-
-
737319
Urbaniak
A novel allosteric inhibitor o ...
Homo sapiens, Trypanosoma brucei, Trypanosoma brucei brucei, Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
ACS Chem. Biol.
8
1981-1987
2013
-
1
3
2
-
-
8
1
-
1
-
1
-
6
-
-
1
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
3
-
1
3
-
2
-
-
3
8
-
1
-
1
-
1
-
-
-
1
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
738089
Humphreys
Mummy, A UDP-N-acetylglucosami ...
Drosophila melanogaster
Dev. Biol.
381
434-445
2013
-
-
1
-
-
-
-
-
-
-
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1
-
5
-
-
-
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2
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1
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1
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1
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3
-
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1
-
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-
-
-
-
-
-
-
-
4
5
-
-
-
739475
Liu
Molecular and functional analy ...
Locusta migratoria
PLoS ONE
8
e71970
2013
-
-
1
-
-
-
-
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1
-
2
2
-
4
-
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1
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2
1
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2
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2
-
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2
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2
2
-
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-
2
-
-
2
2
-
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-
-
-
-
-
2
-
2
4
-
-
-
740866
Jagtap
Crystal structures identify an ...
Mycobacterium tuberculosis
J. Mol. Biol.
425
1745-1759
2013
-
1
-
1
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-
-
-
-
2
-
1
-
1
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1
-
-
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1
1
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1
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1
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2
-
1
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1
1
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1
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1
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643068
Mio
The eukaryotic UDP-N-acetylglu ...
Candida albicans, Homo sapiens, Saccharomyces cerevisiae
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3
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9
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9
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7
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7
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3
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1
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12
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9
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3
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9
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9
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7
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3
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1
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12
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9
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643069
Wang-Gillam
A 17-amino acid insert changes ...
Homo sapiens, Sus scrofa
J. Biol. Chem.
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1998
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1
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2
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4
2
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2
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1
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3
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6
1
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1
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2
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2
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3
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6
1
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643065
Szumilo
Purification to homogeneity an ...
Sus scrofa
J. Biol. Chem.
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13147-13154
1996
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7
1
4
2
2
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1
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1
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8
1
2
5
1
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1
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1
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7
1
4
2
2
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1
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8
1
2
5
1
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1
-
1
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643066
De Luca
Overexpression, one-step purif ...
Escherichia coli
Bioorg. Med. Chem.
4
131-141
1996
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1
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1
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1
3
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2
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1
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1
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4
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1
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1
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1
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1
3
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1
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1
2
4
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1
1
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643064
Ullrich
Identification of the gonococc ...
Neisseria gonorrhoeae
J. Bacteriol.
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6902-6909
1995
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1
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2
1
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4
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2
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1
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2
1
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2
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288685
Mengin-Lecreulx
Copurification of glucosamine- ...
Escherichia coli
J. Bacteriol.
176
5788-5795
1994
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1
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1
1
2
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1
1
3
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1
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1
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1
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5
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1
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1
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1
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1
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2
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1
1
3
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1
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1
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5
-
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1
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-
643062
Yamamoto
Inhibition of UDP-N-acetylgluc ...
Neurospora crassa, Saccharomyces cerevisiae
Biochim. Biophys. Acta
614
367-372
1980
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-
-
-
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8
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4
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6
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6
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8
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4
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6
-
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643061
Yamamoto
Purification and some properti ...
Neurospora crassa, Neurospora crassa IFO 6178
Can. J. Microbiol.
25
1381-1386
1979
4
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1
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2
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3
1
4
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3
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1
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1
2
6
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1
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1
1
1
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4
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1
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2
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3
1
4
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1
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1
2
6
-
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1
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1
1
1
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643060
Yamamoto
-
The effect of magnesium ion on ...
Saccharomyces cerevisiae
J. Ferment. Technol.
56
57-58
1978
1
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2
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1
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1
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1
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1
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2
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1
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1
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1
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2
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643059
Yamamoto
-
Purification and charcterizati ...
Saccharomyces cerevisiae
Agric. Biol. Chem.
40
2275-2281
1976
2
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1
4
2
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3
2
2
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1
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1
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1
2
3
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1
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1
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2
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1
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4
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2
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3
2
2
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1
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1
2
3
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1
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1
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643057
Pattabiraman
Purification of uridine diphos ...
Ovis aries
Biochim. Biophys. Acta
50
129-134
1961
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-
-
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1
3
2
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4
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1
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2
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1
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2
1
2
2
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1
1
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1
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3
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2
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4
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1
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1
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2
1
2
2
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1
1
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643058
Strominger
Uridine diphosphoacetylglucosa ...
Bos taurus, Staphylococcus aureus
J. Biol. Chem.
234
1822-1827
1959
-
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-
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2
1
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3
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2
1
2
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2
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1
2
4
6
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2
1
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2
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1
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3
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2
1
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2
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1
2
4
6
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2
1
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