Literature summary for 2.7.7.23 extracted from

Bulik, D.A.; van Ophem, P.; Manning, J.M.; Shen, Z.; Newburg, D.S.; Jarroll, E.L.
UDP-N-acetylglucosamine pyrophosphorylase, a key enzyme in encysting Giardia, is allosterically regulated (2000), J. Biol. Chem., 275, 14722-14728.

Search for more literature for 2.7.7.23

Activating Compound

Activating Compound	Comment	Organism	Structure
D-glucosamine 6-phosphate	allosteric, 0.003 mM, 5fold increase of activity, reversible by dialysis	Giardia intestinalis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
diphosphate + UDP-N-acetyl-D-glucosamine	Giardia intestinalis	amino sugar metabolism	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate	-	r
diphosphate + UDP-N-acetyl-D-glucosamine	Giardia intestinalis	key enzyme of encystment	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate	-	r

Organism

Organism	UniProt	Comment	Textmining
Giardia intestinalis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
from encysting and non-encysting cells	Giardia intestinalis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diphosphate + UDP-N-acetyl-D-glucosamine	-	Giardia intestinalis	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate	-	r
diphosphate + UDP-N-acetyl-D-glucosamine	amino sugar metabolism	Giardia intestinalis	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate	-	r
diphosphate + UDP-N-acetyl-D-glucosamine	key enzyme of encystment	Giardia intestinalis	UTP + N-acetyl-alpha-D-glucosamine 1-phosphate	-	r

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)