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Literature summary for 2.7.7.19 extracted from

  • Fiedler, M.; Rossmanith, W.; Wahle, E.; Rammelt, C.
    Mitochondrial poly(A) polymerase is involved in tRNA repair (2015), Nucleic Acids Res., 43, 9937-9949.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVV4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293A cell
-
 Homo sapiens
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General Information

General Information Comment Organism
physiological function processing of the common precursor releases an incomplete tRNATyr lacking the 3'-adenosine which has to be added before addition of the CCA end and subsequent aminoacylation. Mitochondrial poly(A) polymerase mtPAP is responsible for this A addition. Complete repair can be reconstituted in vitro with three enzymes: mtPAP frequently adds more than one A to the 3'-end of the truncated tRNA, and either the mitochondrial deadenylase PDE12 or the endonuclease RNase Z trims the oligo(A) tail to a single A before CCA addition Homo sapiens