Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | a terminal poly(A) tail is important for a subset of intron excision events that follow cleavage and polyadenylation. In these cases, splicing is promoted by the nuclear poly(A) binding protein, PABPN1, and poly(A) polymerase, PAP. Poly(A) polymerase is needed for efficient splicing. Inefficient polyadenylation is associated with impaired recruitment of splicing factors to affected introns, which are consequently degraded by the exosome | Homo sapiens |