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Literature summary for 2.7.7.19 extracted from

  • Kim, K.W.; Wilson, T.L.; Kimble, J.
    GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program (2010), Proc. Natl. Acad. Sci. USA, 107, 17445-17450.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans O17087
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General Information

General Information Comment Organism
physiological function removal of either isoform GLD-2 or RNA-binding protein RNP-8 results in shortened poly(A) tails and lowers abundance of four target-mRNAs, i.e. oma-2, egg-1, pup-2, andtra-2. GLD-2 depletion also lowers the abundance of most GLD-2/RNP-8 putative target-mRNAs when assayed on microarrays. The GLD-2/RNP-8 complex is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes Caenorhabditis elegans