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Literature summary for 2.7.7.19 extracted from
- The poly(A) polymerase GLD2 is required for spermatogenesis in Drosophila melanogaster (2011), Development, 138, 1619-1629.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VD44 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | expression in testis, localizes to elongating spermatogenic cysts | Drosophila melanogaster | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GLD2 | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | knockdown of GLD2 transcripts causes male sterility, as GLD2-deficient males do not produce mature sperm. Spermatogenesis up to and including meiosis appears normal in the absence of GLD2, but post-meiotic spermatid development rapidly becomes abnormal. Nuclear bundling and F-actin assembly are defective in GLD2 knockdown testes and nuclei fail to undergo chromatin reorganization in elongated spermatids. GLD2 also affects the incorporation of protamines and the stability of dynamin and transition protein transcripts | Drosophila melanogaster |
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