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Literature summary for 2.7.7.18 extracted from

  • Lau, C.; Dolle, C.; Gossmann, T.; Agledal, L.; Niere, M.; Ziegler, M.
    Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases (2010), J. Biol. Chem., 285, 18868-18876.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa S3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of mutants lacking residues Glu107-Lys146. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoforms NMNAT1 are distributed throughout the cytoplasm Homo sapiens
additional information generation of mutants lacking residues Leu105-Ala125 of isoform NMNAT3. Overexpression of the construct results in a strong increase in overall enzymic activity compared with non-transfected cells Homo sapiens
additional information generation of mutants lacking residues Val109-Leu192. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoform NMNAT2 are distributed throughout the cytoplasm Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isoform NMNAT2 localizes to the cis-Golgi and endoplasmic reticulum-Golgi intermediate compartment. It is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface Homo sapiens 5794
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mitochondrion isoform NMNAT3 is targeted to mitochondria by its N-terminus Homo sapiens 5739
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additional information the three human isoforms NMNAT1-3 are localized to the nucleus, the Golgi complex, and mitochondria. Their genes contain unique exons that encode isoform-specific domains to mediate subcellular targeting and post-translational modifications. These domains are dispensable for catalytic activity Homo sapiens
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nucleus sequence of isoform NMNAT1 contains a predicted nuclear localization signal Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q96T66 isoform NMNAT3
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Homo sapiens Q9BZQ4 isoform NMNAT2
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Homo sapiens Q9HAN9 isoform NMNAT1
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Synonyms

Synonyms Comment Organism
NMNAT1
-
Homo sapiens
NMNAT2
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Homo sapiens
NMNAT3
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Homo sapiens