Cloned (Comment) | Organism |
---|---|
expression in HeLa S3 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of mutants lacking residues Glu107-Lys146. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoforms NMNAT1 are distributed throughout the cytoplasm | Homo sapiens |
additional information | generation of mutants lacking residues Leu105-Ala125 of isoform NMNAT3. Overexpression of the construct results in a strong increase in overall enzymic activity compared with non-transfected cells | Homo sapiens |
additional information | generation of mutants lacking residues Val109-Leu192. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoform NMNAT2 are distributed throughout the cytoplasm | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | isoform NMNAT2 localizes to the cis-Golgi and endoplasmic reticulum-Golgi intermediate compartment. It is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface | Homo sapiens | 5794 | - |
mitochondrion | isoform NMNAT3 is targeted to mitochondria by its N-terminus | Homo sapiens | 5739 | - |
additional information | the three human isoforms NMNAT1-3 are localized to the nucleus, the Golgi complex, and mitochondria. Their genes contain unique exons that encode isoform-specific domains to mediate subcellular targeting and post-translational modifications. These domains are dispensable for catalytic activity | Homo sapiens | - |
- |
nucleus | sequence of isoform NMNAT1 contains a predicted nuclear localization signal | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96T66 | isoform NMNAT3 | - |
Homo sapiens | Q9BZQ4 | isoform NMNAT2 | - |
Homo sapiens | Q9HAN9 | isoform NMNAT1 | - |
Synonyms | Comment | Organism |
---|---|---|
NMNAT1 | - |
Homo sapiens |
NMNAT2 | - |
Homo sapiens |
NMNAT3 | - |
Homo sapiens |