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Literature summary for 2.7.7.15 extracted from

  • Jackowski, S.; Fagone, P.
    CTP:phosphocholine cytidylyltransferase: Paving the way from gene to membrane (2005), J. Biol. Chem., 280, 853-856.
    View publication on PubMed
Search for more literature for 2.7.7.15

Activating Compound

Activating Compound Comment Organism Structure
Lipids regulation of activity by reversible association with membrane lipids Mus musculus
Lipids regulation of activity by reversible association with membrane lipids Homo sapiens
Lipids regulation of activity by reversible association with membrane lipids Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
ceramide short chain ceramides Homo sapiens
ceramide short chain ceramides Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm membrane associated Mus musculus 5737
-
cytoplasm membrane associated Homo sapiens 5737
-
membrane enzyme is activated when bound to vesicles Mus musculus 16020
-
membrane enzyme is activated when bound to vesicles Homo sapiens 16020
-
membrane enzyme is activated when bound to vesicles Arabidopsis thaliana 16020
-
nucleus CCTalpha, CCTbeta is not found in the nucleus Mus musculus 5634
-
nucleus CCTalpha, CCTbeta is not found in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Homo sapiens rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis diphosphate + CDP-choline
-
 ?
CTP + choline phosphate Mus musculus rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility diphosphate + CDP-choline
-
 ?
CTP + choline phosphate Arabidopsis thaliana rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation diphosphate + CDP-choline
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Mus musculus
phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Homo sapiens
phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Arabidopsis thaliana

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell high expression of enzyme Mus musculus
-
alveolar cell high expression of enzyme Homo sapiens
-
brain equal expression of CCT alpha and CCT beta Mus musculus
-
brain equal expression of CCT alpha and CCT beta Homo sapiens
-
additional information CCTalpha expressed in virtually every tissue Mus musculus
-
additional information CCTalpha expressed in virtually every tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
 Mus musculus diphosphate + CDP-choline
-
 ?
CTP + choline phosphate
-
 Homo sapiens diphosphate + CDP-choline
-
 ?
CTP + choline phosphate
-
 Arabidopsis thaliana diphosphate + CDP-choline
-
 ?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis Homo sapiens diphosphate + CDP-choline
-
 ?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility Mus musculus diphosphate + CDP-choline
-
 ?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation Arabidopsis thaliana diphosphate + CDP-choline
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Mus musculus
dimer
-
 Homo sapiens
dimer
-
 Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
More different isoforms, CCTalpha and CCTbeta 1, -2, and -3 Homo sapiens
More different isoforms, CCTalpha and CCTbeta 2 and -3, CCTbeta 1 is not found in mice Mus musculus
More two different isoforms Arabidopsis thaliana