Cloned (Comment) | Organism |
---|---|
wild-type and deletion mutants delta312-367, delta231-367 and delta257-367 | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | DELTA delta257-367 exhibits significantly lower specific activity and can not be activated by lipid, deletion mutant DELTA231-367 can not be activated by lipid | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphatidylcholine | ET-18-OCH3, non-hydrolyzable lysophosphatidylcholine analog, competitive with respect to the lipid activator | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
CTP | delta312-367 mutant, presence of lipid, pH 6.5, 37°C | Rattus norvegicus | |
0.7 | - |
CTP | wild-type, presence of lipid, pH 6.5, 37°C | Rattus norvegicus | |
13.2 | - |
CTP | DELTA257-367 mutant, pH 6.5, 37°C | Rattus norvegicus | |
13.9 | - |
CTP | DELTA312-367 mutant, absence of lipid, pH 6.5, 37°C | Rattus norvegicus | |
19.2 | - |
CTP | DELTA231-367 mutant, pH 6.5, 37°C | Rattus norvegicus | |
24.7 | - |
CTP | wild-type, absence of lipid, pH 6.5, 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + choline phosphate | - |
Rattus norvegicus | diphosphate + CDPcholine | - |
? |