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Literature summary for 2.7.7.14 extracted from
- The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei (2009), Mol. Microbiol., 73, 826-843.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged version expressed in Escherichia coli BL21(DE3) | Trypanosoma brucei |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01209 | - |
ethanolamine-phosphate | - |
Trypanosoma brucei |  |
| 0.01267 | - |
CTP | - |
Trypanosoma brucei | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Trypanosoma brucei | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44623 | - |
1 * 44623, MALDI MS, analytical ultracentrifugation | Trypanosoma brucei |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | B9WNA0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni ion affinity chromatography | Trypanosoma brucei |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.55 | - |
- |
Trypanosoma brucei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + ethanolamine phosphate | - |
Trypanosoma brucei | CDP-ethanolamine + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 44623, MALDI MS, analytical ultracentrifugation | Trypanosoma brucei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ethanolamine-phosphate cytidylyltransferase | - |
Trypanosoma brucei |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.15 | - |
CTP | - |
Trypanosoma brucei | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Trypanosoma brucei |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | important for Kennedy pathway, essential to bloodstream form | Trypanosoma brucei |
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Release 2023.1 (January 2023)
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