Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutanoic acid | - |
Trypanosoma cruzi | |
3-(azetidin-1-yl)-N-(imidazo[1,2-a]pyridin-3-ylmethyl)propan-1-amine | - |
Trypanosoma cruzi | |
4-[3-(3-aminopyrrolidin-1-yl)propoxy]benzoic acid | - |
Trypanosoma cruzi | |
5-(2-amino-1,3-thiazol-4-yl)-2-hydroxybenzyl acetate | - |
Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0133 | - |
alpha-D-mannose 1-phosphate | at pH 7.5 and 25°C | Trypanosoma cruzi | |
0.0407 | - |
GTP | at pH 7.5 and 25°C | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | Trypanosoma cruzi | - |
diphosphate + GDP-mannose | - |
r | |
GTP + alpha-D-mannose 1-phosphate | Trypanosoma cruzi CL Brener | - |
diphosphate + GDP-mannose | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q4CMK4 | - |
- |
Trypanosoma cruzi CL Brener | Q4CMK4 | - |
- |
Purification (Comment) | Organism |
---|---|
HisTrap Ni affinity column chromatography and Superdex 200 gel filtration | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | - |
Trypanosoma cruzi | diphosphate + GDP-mannose | - |
r | |
GTP + alpha-D-mannose 1-phosphate | - |
Trypanosoma cruzi CL Brener | diphosphate + GDP-mannose | - |
r |
Subunits | Comment | Organism |
---|---|---|
hexamer | - |
Trypanosoma cruzi |
Synonyms | Comment | Organism |
---|---|---|
GDP-mannose pyrophosphorylase | - |
Trypanosoma cruzi |
GDP-MP | - |
Trypanosoma cruzi |
guanosine diphosphate-mannose pyrophosphorylase | - |
Trypanosoma cruzi |