Literature summary for 2.7.7.105 extracted from

Braga, D.; Last, D.; Hasan, M.; Guo, H.; Leichnitz, D.; Uzum, Z.; Richter, I.; Schalk, F.; Beemelmanns, C.; Hertweck, C.; Lackner, G.
Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420 (2019), ACS Chem. Biol., 14, 2088-2094 .

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Application

Application	Comment	Organism
synthesis	the 3PG-F420 biosynthetic gene cluster is fully functional in Escherichia coli, enabling convenient production of the cofactor by fermentation	Methanocaldococcus jannaschii
synthesis	the 3PG-F420 biosynthetic gene cluster is fully functional in Escherichia coli, enabling convenient production of the cofactor by fermentation	Mycetohabitans rhizoxinica

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Methanocaldococcus jannaschii
expression in Escherichia coli	Mycetohabitans rhizoxinica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphoenolpyruvate + GTP	Methanocaldococcus jannaschii	-	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?
phosphoenolpyruvate + GTP	Mycetohabitans rhizoxinica	-	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?
phosphoenolpyruvate + GTP	Methanocaldococcus jannaschii ATCC 43067	-	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	Q58297	-	-
Methanocaldococcus jannaschii ATCC 43067	Q58297	-	-
Mycetohabitans rhizoxinica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	CofC from Methanocaldococcus jannaschii accepts 2-phospholactate (96.5%, reaction of EC 2.7.7.68), and phosphoenolpyruvate (3.5%)	Methanocaldococcus jannaschii	?	-	-
additional information	CofC from Paraburkholderia rhizoxinica accepts 3-phosphoglycerate (72.7%), 2-phospholactate (23.4%), and phosphoenolpyruvate (3.9%)	Mycetohabitans rhizoxinica	?	-	-
additional information	CofC from Methanocaldococcus jannaschii accepts 2-phospholactate (96.5%, reaction of EC 2.7.7.68), and phosphoenolpyruvate (3.5%)	Methanocaldococcus jannaschii ATCC 43067	?	-	-
phosphoenolpyruvate + GTP	-	Methanocaldococcus jannaschii	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?
phosphoenolpyruvate + GTP	-	Mycetohabitans rhizoxinica	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?
phosphoenolpyruvate + GTP	-	Methanocaldococcus jannaschii ATCC 43067	enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
cofC	-	Methanocaldococcus jannaschii
cofC	-	Mycetohabitans rhizoxinica
fbiD	-	Methanocaldococcus jannaschii
fbiD	-	Mycetohabitans rhizoxinica

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Release 2023.1 (January 2023)