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Literature summary for 2.7.6.5 extracted from

  • Sy, J.; Akers, H.
    Purification and properties of guanosine 5,3-polyphosphate synthetase from Bacillus brevis (1976), Biochemistry, 15, 4399-4403.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-(beta,gamma-Imino)triphosphate
-
Brevibacillus brevis
dGDP
-
Brevibacillus brevis
dGTP
-
Brevibacillus brevis
Mg2+ required as a counter ion for the nucleoside substrate, excess of Mg2+ is inhibitory Brevibacillus brevis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
GDP 30°C, pH 8.1 Brevibacillus brevis
0.62
-
ATP cosubstrate GDP, pH 8.1, 30°C Brevibacillus brevis
0.71
-
ATP cosubstrate GTP, pH 8.1, 30°C Brevibacillus brevis
0.77
-
GTP 30°C, pH 8.1 Brevibacillus brevis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required as a counter-ion for the nucleoside substrate, excess of Mg2+ is inhibitory Brevibacillus brevis
Mn2+ can partially replace Mg2+ in activation Brevibacillus brevis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
sucrose density gradient centrifugation Brevibacillus brevis

Organism

Organism UniProt Comment Textmining
Brevibacillus brevis
-
ATCC 8185
-

Purification (Commentary)

Purification (Comment) Organism
-
Brevibacillus brevis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Brevibacillus brevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-methyl-ATP + GTP
-
Brevibacillus brevis 2'-methyl-AMP + guanosine 3'-diphosphate 5'-triphosphate
-
?
8-bromo-ATP + GTP
-
Brevibacillus brevis 8-bromo-AMP + guanosine 3'-diphosphate 5'-triphosphate
-
?
ATP + GDP preferred substrate Brevibacillus brevis AMP + guanosine 3'-diphosphate 5'-diphosphate i.e ppGpp ?
ATP + GTP
-
Brevibacillus brevis AMP + guanosine 3'-diphosphate 5'-triphosphate i.e. pppGpp ?
ATP + guanosine 5'-tetraphosphate
-
Brevibacillus brevis AMP + guanosine 3'-diphosphate 5'-tetraphosphate
-
?
ATP + ITP
-
Brevibacillus brevis AMP + inosine 3'-diphosphate 5'-triphosphate
-
?
dATP + GTP
-
Brevibacillus brevis dAMP + guanosine 3'-diphosphate 5'-triphosphate
-
?
additional information no substrate: 5'(beta,gamma-imino)triphosphate, 1,N6-ethyladenosine triphosphate, no diphosphate acceptors: ATP, UTP, CTP, dGTP, dGDP, 2'-O-methyl-GDP, 7-methyl-GDP Brevibacillus brevis ?
-
?