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Literature summary for 2.7.6.2 extracted from

  • Liu, J.; Timm, D.E.; Hurley, T.D.
    Pyrithiamine as a substrate for thiamine pyrophosphokinase (2006), J. Biol. Chem., 281, 6601-6607.
    View publication on PubMed
Search for more literature for 2.7.6.2

Application

Application Comment Organism
additional information Administration of oxythiamine to animals produces primarily metabolic aberrations such as lethargy and anorexia while the administration of pyrithiamine to animals produces neurological problems similar to Wernicke-Korsakoff Syndrome. Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
Crystallization experiments were set up by incubating mouse TPK with pyrithiamine and MgATP2- prior to adding the equilibrium mixture of enzyme, substrate, and products to the previously determined crystallization conditions. Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
pyrithiamine
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thiamine + ATP Mus musculus
-
 thiamine diphosphate + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oxythiamine + ATP
-
 Mus musculus oxythiamine diphosphate + AMP
-
 ?
pyrithiamine + ATP inhibits the substrate thiamine Mus musculus pyrithiamine diphosphate + AMP
-
 ?
thiamine + ATP
-
 Mus musculus thiamine diphosphate + AMP
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
thiamine pyrophosphokinase
-
 Mus musculus