Literature summary for 2.7.6.2 extracted from

Frankhauser, H.; Zurlinden, A.; Schweingruber, A.M.; Edenharter, E.; Schweingruber, M.E.
Schizosaccharomyces pombe thiamin pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamin metabolism, phosphate metabolism, mating, and growth (1995), J. Biol. Chem., 270, 28457-28462.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene tnr3	Schizosaccharomyces pombe

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.006	-	thiamine	pH 8.6, 37°C	Schizosaccharomyces pombe
1.9	-	ATP	pH 8.6, 37°C	Schizosaccharomyces pombe

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	Km: 3 mM	Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + thiamine	Schizosaccharomyces pombe	the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth	AMP + thiamine diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	P41888	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + thiamine	-	Schizosaccharomyces pombe	AMP + thiamine diphosphate	-	?
ATP + thiamine	the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth	Schizosaccharomyces pombe	AMP + thiamine diphosphate	-	?

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Release 2026.1 (March 2026)