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Literature summary for 2.7.6.1 extracted from

  • de Brouwer, A.P.; Williams, K.L.; Duley, J.A.; van Kuilenburg, A.B.; Nabuurs, S.B.; Egmont-Petersen, M.; Lugtenberg, D.; Zoetekouw, L.; Banning, M.J.; Roeffen, M.; Hamel, B.C.; Weaving, L.; Ouvrier, R.A.; Donald, J.A.; Wevers, R.A.; Christodoulou, J.; van Bokhoven, H.
    Arts syndrome is caused by loss-of-function mutations in PRPS1 (2007), Am. J. Hum. Genet., 81, 507-518.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
diadenosine pentaphosphate Inhibits the dephosphorylation of ATP and ADP by nonspecific phosphatases. Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ribose-5-phosphate + ATP Homo sapiens first step in purine metabolic pathway phosphoribosyldiphosphate + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P60891
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EBV-LCL cell
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribose-5-phosphate + ATP first step in purine metabolic pathway Homo sapiens phosphoribosyldiphosphate + AMP
-
 ?

Synonyms

Synonyms Comment Organism
phosphoribosyl pyrophosphate synthase 1 (PRS-1)
-
 Homo sapiens