Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Pseudomonas aeruginosa |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 30% (w/v) PEG 4000, 0.2 M MgCl2, and 0.1 M Tris, pH 7.5-8.5, at 22°C | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3,4-dichlorophenyl)-3-[[(2R,3R,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea | - |
Pseudomonas aeruginosa | |
1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
1-[(4aR,5S,7R,7aS)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Pseudomonas aeruginosa | |
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid | - |
Pseudomonas aeruginosa | |
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid | - |
Pseudomonas aeruginosa | |
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid | - |
Pseudomonas aeruginosa | |
2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | - |
Pseudomonas aeruginosa | |
2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid | - |
Pseudomonas aeruginosa | |
2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid | - |
Pseudomonas aeruginosa | |
3'-azido-3'-deoxy-thymidine-5'-monophosphate | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide | - |
Pseudomonas aeruginosa | |
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide | - |
Pseudomonas aeruginosa | |
3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid | - |
Pseudomonas aeruginosa | |
3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | - |
Pseudomonas aeruginosa | |
4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide | - |
Pseudomonas aeruginosa | |
4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | - |
Pseudomonas aeruginosa | |
6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | - |
Pseudomonas aeruginosa | |
deoxy-fluorothymidine | - |
Pseudomonas aeruginosa | |
dTMP | - |
Pseudomonas aeruginosa | |
methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate | - |
Pseudomonas aeruginosa | |
N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide | - |
Pseudomonas aeruginosa | |
N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | - |
Pseudomonas aeruginosa | |
P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate | - |
Pseudomonas aeruginosa | |
thiourea-alpha-TM | - |
Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q9HZN8 | - |
- |
Purification (Comment) | Organism |
---|---|
HisTrap column chromatography and Superdex 200 gel filtration | Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTMP | - |
Pseudomonas aeruginosa | ADP + dTDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thymidylate kinase | - |
Pseudomonas aeruginosa |
TMK | - |
Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00012 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide | |
0.00012 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.00016 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide | |
0.0002 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.00025 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid | |
0.00037 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate | |
0.00044 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide | |
0.00051 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide | |
0.00081 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.00088 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.00088 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid | |
0.00099 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.001 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | |
0.0013 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid | |
0.002 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide | |
0.002 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | |
0.0021 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | |
0.0022 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | |
0.0022 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.0023 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.0024 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | |
0.0026 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid | |
0.0026 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | |
0.0027 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid | |
0.0029 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide | |
0.003 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.0032 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide | |
0.0032 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.0034 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide | |
0.0049 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.005 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid | |
0.0058 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide | |
0.0062 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide | |
0.011 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.012 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid | |
0.013 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.02 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | deoxy-fluorothymidine | |
0.021 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.037 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one | |
0.058 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.063 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.066 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.068 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide | |
0.104 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide | |
0.152 | - |
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C | Pseudomonas aeruginosa | 4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide |