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Literature summary for 2.7.4.9 extracted from

  • Choi, J.Y.; Plummer, M.S.; Starr, J.; Desbonnet, C.R.; Soutter, H.; Chang, J.; Miller, J.R.; Dillman, K.; Miller, A.A.; Roush, W.R.
    Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation (2012), J. Med. Chem., 55, 852-870.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 30% (w/v) PEG 4000, 0.2 M MgCl2, and 0.1 M Tris, pH 7.5-8.5, at 22°C Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
1-(3,4-dichlorophenyl)-3-[[(2R,3R,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
 Pseudomonas aeruginosa
1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
1-[(4aR,5S,7R,7aS)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Pseudomonas aeruginosa
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid
-
 Pseudomonas aeruginosa
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid
-
 Pseudomonas aeruginosa
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
-
 Pseudomonas aeruginosa
2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
 Pseudomonas aeruginosa
2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid
-
 Pseudomonas aeruginosa
2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid
-
 Pseudomonas aeruginosa
3'-azido-3'-deoxy-thymidine-5'-monophosphate
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide
-
 Pseudomonas aeruginosa
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide
-
 Pseudomonas aeruginosa
3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
-
 Pseudomonas aeruginosa
3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
 Pseudomonas aeruginosa
4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
-
 Pseudomonas aeruginosa
4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
 Pseudomonas aeruginosa
6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
 Pseudomonas aeruginosa
deoxy-fluorothymidine
-
 Pseudomonas aeruginosa
dTMP
-
 Pseudomonas aeruginosa
methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate
-
 Pseudomonas aeruginosa
N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide
-
 Pseudomonas aeruginosa
N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
 Pseudomonas aeruginosa
P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate
-
 Pseudomonas aeruginosa
thiourea-alpha-TM
-
 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HZN8
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Superdex 200 gel filtration Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dTMP
-
 Pseudomonas aeruginosa ADP + dTDP
-
 ?

Synonyms

Synonyms Comment Organism
thymidylate kinase
-
 Pseudomonas aeruginosa
TMK
-
 Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00012
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide
0.00012
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.00016
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide
0.0002
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.00025
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid
0.00037
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate
0.00044
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
0.00051
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide
0.00081
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.00088
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.00088
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid
0.00099
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.001
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
0.0013
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid
0.002
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide
0.002
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
0.0021
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
0.0022
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
0.0022
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.0023
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.0024
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
0.0026
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
0.0026
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
0.0027
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
0.0029
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide
0.003
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.0032
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
0.0032
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.0034
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide
0.0049
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.005
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
0.0058
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide
0.0062
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide
0.011
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.012
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid
0.013
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.02
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa deoxy-fluorothymidine
0.021
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.037
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one
0.058
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.063
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.066
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.068
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
0.104
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
0.152
-
 in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide
0.2
-
 IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C Pseudomonas aeruginosa 4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide