BRENDA - Enzyme Database show
show all sequences of 2.7.4.9

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

Van Poecke, S.; Munier-Lehmann, H.; Helynck, O.; Froeyen, M.; Van Calenbergh, S.; Bioorg. Med. Chem. 19, 7603-7611 (2011)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
-
Mycobacterium tuberculosis
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
-
Mycobacterium tuberculosis
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
-
Mycobacterium tuberculosis
3'-azido-3'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
-
Mycobacterium tuberculosis
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
-
Mycobacterium tuberculosis
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
Mycobacterium tuberculosis
additional information
not inhibited by N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-phenylthiourea
Mycobacterium tuberculosis
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
-
Mycobacterium tuberculosis
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium tuberculosis
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dTMP
-
721834
Mycobacterium tuberculosis
ADP + dTDP
-
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00017
-
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0006
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0021
-
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0023
-
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0027
-
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0028
-
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0042
-
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.005
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.006
-
3'-azido-3'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.009
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0099
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.015
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0265
-
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.028
-
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.035
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.037
-
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.045
-
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.073
-
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.1
-
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
Ki above 0.1 mM, in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.201
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
-
Mycobacterium tuberculosis
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
-
Mycobacterium tuberculosis
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
-
Mycobacterium tuberculosis
3'-azido-3'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
-
Mycobacterium tuberculosis
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
-
Mycobacterium tuberculosis
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
-
Mycobacterium tuberculosis
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
Mycobacterium tuberculosis
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
Mycobacterium tuberculosis
additional information
not inhibited by N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-phenylthiourea
Mycobacterium tuberculosis
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
-
Mycobacterium tuberculosis
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00017
-
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0006
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0021
-
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0023
-
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0027
-
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0028
-
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0042
-
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.005
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.006
-
3'-azido-3'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.009
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0099
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.015
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.0265
-
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.028
-
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.035
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.037
-
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.045
-
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.073
-
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.1
-
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
Ki above 0.1 mM, in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
0.201
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37C
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dTMP
-
721834
Mycobacterium tuberculosis
ADP + dTDP
-
-
-
?
Other publictions for EC 2.7.4.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738404
Doharey
Insights into the structure-fu ...
Wolbachia endosymbiont of Brugia malayi, Wolbachia endosymbiont of Brugia malayi TRS
Int. J. Biol. Macromol.
88
565-571
2016
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
738163
Singh
Synthesis, molecular docking a ...
Wolbachia endosymbiont of Brugia malayi, Wolbachia endosymbiont of Brugia malayi TRS
Eur. J. Med. Chem.
93
74-82
2015
-
-
-
1
-
-
3
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
3
3
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738558
Guevara-Hernandez
A novel viral thymidylate kina ...
white spot syndrome virus
J. Bioenerg. Biomembr.
47
431-440
2015
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
738844
Naik
Structure guided lead generati ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
58
753-766
2015
-
-
-
1
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737398
Doharey
Molecular cloning and characte ...
Wolbachia endosymbiont of Brugia malayi, Wolbachia endosymbiont of Brugia malayi TRS
Acta Trop.
133
83-92
2014
-
-
1
-
-
-
10
2
-
5
2
-
-
4
-
-
-
-
-
-
-
-
8
1
1
1
1
1
1
1
-
-
5
-
5
-
-
1
-
-
-
-
5
10
5
2
-
5
2
-
-
-
-
-
-
-
-
-
8
1
1
1
1
1
1
1
-
-
-
-
-
-
2
2
738831
Kawatkar
Antibacterial inhibitors of Gr ...
Staphylococcus aureus
J. Med. Chem.
57
4584-4597
2014
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
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Quantitative structure-activit ...
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2014
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Synthesis and evaluation of 5- ...
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Chaudhary
Cloning, expression, purificat ...
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Noguchi
Synthesis of carbocyclic pyrim ...
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62
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Sato
The engineered thymidylate kin ...
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Structure guided development o ...
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Kato
Carbocyclic thymidine derivati ...
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13
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7
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723714
Guevara-Hernandez
Biochemical characterization o ...
white spot syndrome virus
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2012
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721198
Leibly
Structure of thymidylate kinas ...
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Kandeel
The substrate binding preferen ...
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Van Poecke
Synthesis and inhibitory activ ...
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Topalis
Novel antiviral C5-substituted ...
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Kohler
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1
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1
1
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1
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Familiar
Design, synthesis and inhibito ...
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1
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9
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9
9
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Chien
The yeast Cdc8 exhibits both d ...
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2281-2286
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1
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1
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2
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1
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1
1
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2
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1
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1
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Rational design and 3D-pharmac ...
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Kandeel
Thymidylate kinase: the lost c ...
Anaplasma marginale, Plasmodium falciparum
Nucleic Acids Symp. Ser.
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283-284
2009
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2
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2
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2
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2
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2
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4
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2
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Meyer
Structural basis for the speci ...
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Nucleic Acids Symp. Ser.
53
41
2009
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706813
Wayengera
Theoretical basis for reducing ...
Mycobacterium tuberculosis
Theor. Biol. Med. Model.
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2009
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1
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1
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691226
Gasse
Substituted benzyl-pyrimidines ...
Homo sapiens, Mycobacterium tuberculosis
Bioorg. Med. Chem.
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6075-6085
2008
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16
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Hu
Synthetic lethality by lentivi ...
Homo sapiens
Cancer Res.
68
2831-2840
2008
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1
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1
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1
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1
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1
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691813
Familiar
Exploring acyclic nucleoside a ...
Homo sapiens, Mycobacterium tuberculosis
ChemMedChem
3
1083-1093
2008
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2
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2
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3
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7
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8
7
2
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2
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692491
Chen
Identification of a putative h ...
Homo sapiens
Genes Cells
13
679-689
2008
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1
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1
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2
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2
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2
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1
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1
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2
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2
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692915
Kandeel
Molecular characterization, he ...
Plasmodium falciparum
J. Biochem.
144
245-250
2008
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1
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4
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4
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4
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2
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1
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5
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4
1
6
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2
4
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693440
Lavie
Restoration of the antiviral a ...
Escherichia coli, Homo sapiens
J. Gen. Virol.
89
1672-1679
2008
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2
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2
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12
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694480
Byun
Synthesis and Biological Evalu ...
Bacillus anthracis
Nucleosides Nucleotides Nucleic Acids
27
244-260
2008
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694670
Ronceret
The first zygotic division in ...
Arabidopsis thaliana
Plant J.
53
776-789
2008
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1
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1
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2
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Carnrot
Mechanisms of substrate select ...
Bacillus anthracis
Protein Sci.
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2008
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12
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706485
Caillat
Crystal structure of poxvirus ...
Vaccinia virus
Proc. Natl. Acad. Sci. USA
105
16900-16905
2008
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1
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1
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7
7
1
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1
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6
1
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1
1
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676227
Alexandre
Enantioselectivity of human AM ...
Homo sapiens
Nucleic Acids Res.
35
4895-4904
2007
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2
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692409
Collins
Isolation of a novel fish thym ...
Salmo salar
Fish Shellfish Immunol.
23
793-807
2007
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693534
Van Daele
Rational design of 5-thiourea- ...
Homo sapiens, Mycobacterium tuberculosis
J. Med. Chem.
50
5281-5292
2007
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19
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19
19
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694282
Sato
Engineered human tmpk/AZT as a ...
Homo sapiens
Mol. Ther.
15
962-970
2007
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1
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1
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673092
Van Daele
Synthesis and biological evalu ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis
ChemMedChem
1
1081-1090
2006
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1
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3
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1
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1
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677021
Kotaka
Structures of S. aureus thymid ...
Staphylococcus aureus
Protein Sci.
15
774-784
2006
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1
1
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6
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1
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1
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1
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1
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1
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661170
Fioravanti
The crystal structure of Mycob ...
Mycobacterium tuberculosis
Biochemistry
44
130-137
2005
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1
-
1
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-
3
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1
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1
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3
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2
1
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1
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1
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3
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1
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1
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2
1
-
-
-
-
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662597
Vanheusden
Discovery of bicyclic thymidin ...
Homo sapiens, Mycobacterium tuberculosis
J. Med. Chem.
47
6187-6194
2004
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2
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3
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1
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3
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5
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20
-
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1
2
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28
20
3
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1
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2
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5
-
-
-
-
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-
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662794
Lavie
Structural requirements for ef ...
Homo sapiens
Mini Rev. Med. Chem.
4
351-359
2004
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1
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1
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4
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2
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1
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1
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-
2
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-
-
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-
645200
Ostermann
Structures of human thymidylat ...
Homo sapiens
Biochemistry
42
2568-2577
2003
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-
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-
-
-
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8
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2
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6
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6
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8
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6
-
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6
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-
645204
Fioravanti
Mycobacterium tuberculosis thy ...
Mycobacterium tuberculosis
J. Mol. Biol.
327
1077-1092
2003
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1
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1
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3
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1
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1
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-
-
-
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-
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-
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661477
Pochet
Comparative study of purine an ...
Homo sapiens, Mycobacterium tuberculosis
ChemBioChem
4
742-747
2003
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1
1
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11
1
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2
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4
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1
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4
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-
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10
-
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1
1
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-
-
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-
11
10
1
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-
2
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1
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-
-
-
4
-
-
-
-
-
-
-
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662169
Haouz
Enzymatic and structural analy ...
Mycobacterium tuberculosis
J. Biol. Chem.
278
4963-4971
2003
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1
1
1
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4
2
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1
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1
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4
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1
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-
-
-
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2
1
-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
1
-
-
-
4
2
2
-
1
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662987
Munier-Lehmann
Design of Mycobacterium tuberc ...
Mycobacterium tuberculosis
Nucleosides Nucleotides Nucleic Acids
22
801-804
2003
-
-
-
-
-
-
20
-
-
-
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1
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2
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-
-
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2
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19
-
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-
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-
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-
20
19
-
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-
1
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-
-
2
-
-
-
-
-
-
-
-
-
-
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-
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663399
Gardberg
Structural basis for the dual ...
Equid alphaherpesvirus 4, Herpes simplex virus
Structure
11
1265-1277
2003
-
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1
1
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1
6
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2
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1
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6
1
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-
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-
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-
1
-
1
-
-
-
-
-
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1
6
-
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-
1
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-
-
-
6
1
-
-
-
-
-
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645203
Petit
Characterization of Streptococ ...
Streptococcus pneumoniae
Biochem. J.
363
825-831
2002
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1
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3
2
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1
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1
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6
-
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-
2
1
1
-
-
3
-
-
-
-
1
-
-
-
-
-
3
3
2
-
-
-
1
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-
1
-
-
-
-
6
-
-
-
-
2
1
1
-
-
-
-
-
-
-
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645207
Munier-lehmann
Thymidylate kinase of Mycobact ...
Mycobacterium tuberculosis
Protein Sci.
10
1195-1205
2001
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1
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1
3
2
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2
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4
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1
1
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-
1
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-
-
2
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-
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-
1
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-
-
1
-
3
2
2
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2
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-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
645208
Ostermann
Insights into the phosphoryltr ...
Homo sapiens
Structure
8
629-642
2000
-
-
-
1
-
-
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-
-
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2
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-
-
-
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-
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-
-
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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645201
Chenal-FRancisque
The highly similar TMP kinase ...
Escherichia coli, Yersinia pestis
Eur. J. Biochem.
265
112-119
1999
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1
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11
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1
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22
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3
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1
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11
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2
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1
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22
-
-
-
3
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-
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-
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-
-
-
-
-
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645205
terentyev
Purification and some properti ...
Strongylocentrotus intermedius
Biochemistry
64
80-85
1999
-
-
-
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3
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5
1
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2
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2
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4
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1
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3
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5
1
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2
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4
-
-
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1
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645202
Tourneux
Substitution of an alanine res ...
Escherichia coli
J. Bacteriol.
180
4291-4293
1998
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3
1
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2
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1
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1
1
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7
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3
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3
1
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-
2
-
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-
645206
Jacobsson
Decreas in thymidylate kinase ...
Homo sapiens
Biochem. Pharmacol.
56
389-395
1998
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-
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1
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1
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-
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-
-
-
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-
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645189
Tamiya
Co-purification of thymidylate ...
Homo sapiens
Biochim. Biophys. Acta
995
28-35
1989
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5
2
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2
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1
1
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7
1
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5
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2
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1
1
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7
1
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641085
Bone
Inhibition of adenosine and th ...
Homo sapiens
J. Biol. Chem.
261
16410-16413
1986
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3
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1
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1
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6
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3
6
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1
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-
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645191
Jong
Characterization of Saccharomy ...
Saccharomyces cerevisiae
J. Biol. Chem.
259
14394-14398
1984
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10
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6
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9
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2
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1
1
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1
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10
1
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3
6
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9
-
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2
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1
1
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645199
Jong
The CDC8 gene of yeast encodes ...
Saccharomyces cerevisiae
J. Biol. Chem.
259
11052-11059
1984
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3
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1
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1
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1
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3
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1
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1
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-
1
-
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-
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645197
de Groot
Thymidylate kinase from Acetab ...
Acetabularia acetabulum
J. Cell Sci.
64
13-25
1983
1
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1
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2
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1
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1
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1
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1
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645192
Chen
Kinetic studies of herpes simp ...
Human alphaherpesvirus 1
J. Biol. Chem.
254
10747-10753
1979
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6
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1
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1
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7
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6
7
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1
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645193
Lee
Human thymidylate kinase. Puri ...
Homo sapiens
J. Biol. Chem.
252
5686-5691
1977
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5
4
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1
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1
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1
1
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3
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1
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5
1
4
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1
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1
1
-
3
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645194
Smith
Partial purification and chara ...
Gallus gallus
Arch. Biochem. Biophys.
167
61-71
1975
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-
-
-
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1
4
1
-
2
1
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1
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1
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1
1
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1
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1
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4
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1
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2
1
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1
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1
1
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1
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645195
Rossi
Enzymes of deoxythymidine trip ...
Neurospora crassa
J. Bacteriol.
121
640-647
1975
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-
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1
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2
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1
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645196
Cheng
Mouse ascites sarcoma 180 thym ...
Mus musculus
Biochemistry
12
2612-2619
1973
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1
8
2
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1
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1
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1
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1
1
1
6
-
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1
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5
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1
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8
5
2
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1
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1
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1
1
1
6
-
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1
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645188
Kielley
Purification and properties of ...
Mus musculus
J. Biol. Chem.
245
4204-4212
1970
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2
10
1
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1
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2
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1
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1
1
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3
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1
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1
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2
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10
1
1
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1
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1
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1
1
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3
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1
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645198
Nelson
Purification and characterizat ...
Escherichia coli, Escherichia coli B / ATCC 11303
J. Biol. Chem.
244
5254-5262
1969
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6
2
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3
1
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177
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1
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2
13
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1
1
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1
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6
1
2
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3
1
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1
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2
13
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1
1
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