Literature summary for 2.7.4.9 extracted from

Kandeel, M.; Kato, A.; Kitamura, Y.; Kitade, Y.
Thymidylate kinase: the lost chemotherapeutic target (2009), Nucleic Acids Symp. Ser., 53, 283-284.

Search for more literature for 2.7.4.9

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione	-	Anaplasma marginale
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione	-	Plasmodium falciparum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.022	-	TMP	-	Plasmodium falciparum
0.03	-	dGMP	-	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Anaplasma marginale	-	-	-
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + dGMP	-	Plasmodium falciparum	ADP + dGDP	-	?
ATP + dGMP	-	Anaplasma marginale	ADP + dGDP	-	?
ATP + TMP	-	Plasmodium falciparum	ADP + TDP	-	?
ATP + TMP	-	Anaplasma marginale	ADP + TDP	-	?

Synonyms

Synonyms	Comment	Organism
thymidylate kinase	-	Plasmodium falciparum
thymidylate kinase	-	Anaplasma marginale
TMK	-	Plasmodium falciparum
TMK	-	Anaplasma marginale

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
2.9	-	dGMP	-	Plasmodium falciparum
3.4	-	TMP	-	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Plasmodium falciparum
ATP	-	Anaplasma marginale

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Release 2023.1 (January 2023)