Literature summary for 2.7.4.9 extracted from

Andrade, C.H.; Pasqualoto, K.F.; Ferreira, E.I.; Hopfinger, A.J.
Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors (2009), J. Chem. Inf. Model., 49, 1070-1078.

Inhibitors

Inhibitors	Comment	Organism
1,3-bis[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea	-	Mycobacterium tuberculosis
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea	-	Mycobacterium tuberculosis
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea	-	Mycobacterium tuberculosis
1-[(2S,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione	-	Mycobacterium tuberculosis
1-[(2S,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione	-	Mycobacterium tuberculosis
1-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]-3-phenylthiourea	-	Mycobacterium tuberculosis
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]thiourea	-	Mycobacterium tuberculosis
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea	-	Mycobacterium tuberculosis
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]urea	-	Mycobacterium tuberculosis
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methoxyphenyl)thiourea	-	Mycobacterium tuberculosis
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methylphenyl)thiourea	-	Mycobacterium tuberculosis
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea	-	Mycobacterium tuberculosis
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-pyridin-3-ylthiourea	-	Mycobacterium tuberculosis
1-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]-3-phenylthiourea	-	Mycobacterium tuberculosis
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine	-	Mycobacterium tuberculosis
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine	-	Mycobacterium tuberculosis
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine	-	Mycobacterium tuberculosis
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine	-	Mycobacterium tuberculosis
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine	-	Mycobacterium tuberculosis
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine	-	Mycobacterium tuberculosis
5'-([[4-chloro-3-(trifluoromethyl)benzyl]carbamothioyl]amino)-5'-deoxythymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-([[2-(3,4-dichlorophenyl)ethyl]carbamothioyl]amino)thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[[(2-phenylethyl)carbamothioyl]amino]thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[[(3,4-dichlorophenyl)carbamoyl]amino]thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[[(4-morpholin-4-ylphenyl)carbamothioyl]amino]thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine	-	Mycobacterium tuberculosis
5'-deoxy-5'-[[(phenylcarbonyl)carbamothioyl]amino]thymidine	-	Mycobacterium tuberculosis
5'-[(benzylcarbamothioyl)amino]-5'-deoxythymidine	-	Mycobacterium tuberculosis
5'-[([[9-(2-carboxyphenyl)-3-oxo-2,3-dihydro-1H-xanthen-6-yl]oxy]carbamothioyl)amino]-5'-deoxythymidine	-	Mycobacterium tuberculosis
N-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]benzamide	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WKE1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + dTMP	-	Mycobacterium tuberculosis	ADP + dTDP	-	?

Synonyms

Synonyms	Comment	Organism
thymidine monophosphate kinase	-	Mycobacterium tuberculosis
TMPK	-	Mycobacterium tuberculosis

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mycobacterium tuberculosis