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Literature summary for 2.7.4.8 extracted from
- A novel Escherichia coli strain allows functional analysis of guanylate kinase drug resistance and sensitivity (2003), Anal. Biochem., 322, 40-47.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + GMP | Escherichia coli | signal transduction | ADP + GDP | - |
? |  |
| ATP + GMP | Escherichia coli TS202A | signal transduction | ADP + GDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
guanylate-kinase-deficient | - |
| Escherichia coli TS202A | - |
guanylate-kinase-deficient | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + GMP | signal transduction | Escherichia coli | ADP + GDP | - |
? | |
| ATP + GMP | signal transduction | Escherichia coli TS202A | ADP + GDP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GMK | - |
Escherichia coli |
| guanylate kinase | - |
Escherichia coli |
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