BRENDA - Enzyme Database show
show all sequences of 2.7.4.8

The partial purification of deoxynucleoside monophosphate kinases from L cells

Griffith, T.J.; Helleiner, C.W.; Biochim. Biophys. Acta 108, 114-124 (1965)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
no activation by EDTA
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
ATP
-
Mus musculus
EDTA
-
Mus musculus
p-hydroxymercuribenzoate
no effect at 0.25 mM, 30% activity at 2.5 mM
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.072
-
dGMP
pH 8.0, 37ºC
Mus musculus
0.26
-
GMP
pH 8.0, 37ºC
Mus musculus
1
-
ATP
pH 8.0, 37ºC, dGMP kinase activity
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
10% as effective as Mg2+
Mus musculus
Co2+
less than 7% as effective as Mg2+
Mus musculus
Fe2+
activation, 90% as effective as Mg2+
Mus musculus
Fe3+
activation, less than 7% as effective as Mg2+
Mus musculus
K+
activation; activity of dGMP kinase progressively enhanced as the concentration of KCl is increased to 250 mM, GMP phosphorylation unaffected; dGMP, not GMP as substrate
Mus musculus
Mg2+
requirement
Mus musculus
Mn2+
equally effective as Mg2+; requirement
Mus musculus
Zn2+
less than 7% as effective as Mg2+
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
mouse
-
Purification (Commentary)
Commentary
Organism
partial by a method that includes DEAE-cellulose chromatography
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
fibroblast
strain L60TM, a subline of Earle's L-strain, i.e. L-cells
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.24
-
-
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dGMP
-
642684
Mus musculus
ADP + dGDP
-
-
-
r
ATP + GMP
specificity
642684
Mus musculus
ADP + GDP
-
-
-
?
ATP + GMP
AMP is no acceptor substrate
642684
Mus musculus
ADP + GDP
-
-
-
?
ATP + GMP
dAMP is no acceptor substrate
642684
Mus musculus
ADP + GDP
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mus musculus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
80
-
incubation for 2 min, 5 min, 10 min or 20 min leads to 43%, 67%, 89% or 97% loss of activity, respectively, 30 min: inactivation
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
equal activity in Tris-HCl buffer and 3,3-dimethylglutarate buffer
Mus musculus
8
-
assay at
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
no activation by EDTA
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ATP
-
Mus musculus
EDTA
-
Mus musculus
p-hydroxymercuribenzoate
no effect at 0.25 mM, 30% activity at 2.5 mM
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.072
-
dGMP
pH 8.0, 37ºC
Mus musculus
0.26
-
GMP
pH 8.0, 37ºC
Mus musculus
1
-
ATP
pH 8.0, 37ºC, dGMP kinase activity
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
10% as effective as Mg2+
Mus musculus
Co2+
less than 7% as effective as Mg2+
Mus musculus
Fe2+
activation, 90% as effective as Mg2+
Mus musculus
Fe3+
activation, less than 7% as effective as Mg2+
Mus musculus
K+
activation; activity of dGMP kinase progressively enhanced as the concentration of KCl is increased to 250 mM, GMP phosphorylation unaffected; dGMP, not GMP as substrate
Mus musculus
Mg2+
requirement
Mus musculus
Mn2+
equally effective as Mg2+; requirement
Mus musculus
Zn2+
less than 7% as effective as Mg2+
Mus musculus
Purification (Commentary) (protein specific)
Commentary
Organism
partial by a method that includes DEAE-cellulose chromatography
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
fibroblast
strain L60TM, a subline of Earle's L-strain, i.e. L-cells
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.24
-
-
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dGMP
-
642684
Mus musculus
ADP + dGDP
-
-
-
r
ATP + GMP
specificity
642684
Mus musculus
ADP + GDP
-
-
-
?
ATP + GMP
AMP is no acceptor substrate
642684
Mus musculus
ADP + GDP
-
-
-
?
ATP + GMP
dAMP is no acceptor substrate
642684
Mus musculus
ADP + GDP
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Mus musculus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
80
-
incubation for 2 min, 5 min, 10 min or 20 min leads to 43%, 67%, 89% or 97% loss of activity, respectively, 30 min: inactivation
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
equal activity in Tris-HCl buffer and 3,3-dimethylglutarate buffer
Mus musculus
8
-
assay at
Mus musculus
Other publictions for EC 2.7.4.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738145
Jain
Insights into open/closed conf ...
Homo sapiens
Eur. Biophys. J.
45
81-89
2016
-
-
1
-
-
-
1
-
-
1
1
1
-
2
-
-
1
-
-
-
-
-
1
1
1
-
-
-
1
-
-
1
-
-
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-
-
1
1
-
-
-
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1
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
3
3
-
-
-
739667
Zhang
Mechanistic insight into the f ...
Saccharomyces cerevisiae
Sci. Rep.
5
8405
2015
-
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-
-
1
-
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1
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1
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1
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-
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2
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1
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1
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1
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-
-
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1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738614
Nomura
Diversity in guanosine 3,5-bis ...
Arabidopsis thaliana, Bacillus subtilis, Escherichia coli, Oryza sativa Japonica Group, Oryza sativa Japonica Group Nipponbare, Pisum sativum, Saccharomyces cerevisiae, Synechococcus elongatus
J. Biol. Chem.
289
15631-15641
2014
-
-
7
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-
-
9
4
9
7
-
11
-
20
-
-
7
-
-
3
-
-
11
-
7
-
-
4
7
-
-
7
1
-
1
-
-
9
9
-
-
-
1
9
1
4
9
9
-
11
-
-
-
9
-
5
-
-
11
-
9
-
-
4
9
-
-
-
-
10
14
-
4
4
739240
Gupta
Purification and characterizat ...
Brugia malayi
Parasitology
141
1341-1352
2014
-
-
1
-
-
-
8
2
-
2
2
1
-
3
-
-
1
1
-
-
-
-
6
2
1
1
-
2
1
1
-
1
-
-
-
-
-
1
1
-
-
-
-
8
-
2
-
2
2
1
-
-
-
1
-
-
-
-
6
2
1
1
-
2
1
1
-
-
-
1
1
-
2
2
737590
Mori
Crystal structure of the guany ...
Homo sapiens
Biochem. Biophys. Res. Commun.
435
334-338
2013
-
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1
1
-
-
-
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2
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-
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3
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1
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1
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1
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-
-
-
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-
-
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-
-
-
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3
3
-
-
-
723031
Dembowski
Alternative splicing of a nove ...
Homo sapiens
J. Nucleic Acids
2012
816237
2012
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721551
Mertlikova-Kaiserova
Point mutations in human guany ...
Homo sapiens
Biochem. Pharmacol.
82
131-138
2011
-
-
1
-
1
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-
2
-
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1
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2
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2
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1
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1
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1
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2
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1
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-
2
-
-
1
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
722117
Zhu
Guanylate kinase domains of th ...
Homo sapiens, Rattus norvegicus
EMBO J.
30
4986-4997
2011
-
-
2
2
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-
-
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2
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2
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2
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2
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2
2
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723014
Kandeel
Binding dynamics and energetic ...
Plasmodium falciparum
J. Mol. Recognit.
24
322-332
2011
-
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1
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2
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2
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700079
Kandeel
Molecular cloning, expression, ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
159
130-133
2008
-
-
1
-
4
-
8
11
-
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1
-
2
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2
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4
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10
1
1
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2
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1
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4
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8
2
11
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1
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2
-
4
-
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10
1
1
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-
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-
-
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700475
Gardoni
Postsynaptic density-membrane ...
Homo sapiens, Mus musculus, Rattus norvegicus
Neuroscience
158
324-333
2008
-
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1
-
1
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4
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4
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3
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3
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6
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5
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1
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1
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1
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4
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6
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5
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1
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700950
Gonzalez-Gutierrez
The guanylate kinase domain of ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
105
14198-14203
2008
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1
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1
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3
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2
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672643
Choi
Guanylate kinase, induced fit, ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biophys. J.
92
1651-1658
2007
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1
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1
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3
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1
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7
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7
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675510
Sumita
Synaptic scaffolding molecule ...
Rattus norvegicus
J. Neurochem.
100
154-166
2007
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1
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3
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1
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5
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1
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1
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1
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5
-
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1
1
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676138
Reese
The guanylate kinase domain of ...
Rattus norvegicus
Nat. Struct. Mol. Biol.
14
155-163
2007
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1
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1
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1
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1
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700744
Sugimoto
The rice nuclear gene, VIRESCE ...
Oryza sativa
Plant J.
52
512-527
2007
-
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1
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6
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3
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5
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6
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3
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671155
El Omari
Structure of Staphylococcus au ...
Staphylococcus aureus
Acta Crystallogr. Sect. F
F62
949-953
2006
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1
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1
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3
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1
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1
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2
1
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672440
Hible
Crystal structures of GMP kina ...
Escherichia coli
Biochimie
88
1157-1164
2006
-
1
-
1
-
-
1
-
-
-
-
2
-
3
-
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-
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2
2
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1
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1
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1
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1
1
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2
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-
-
2
2
-
-
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-
-
-
-
-
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673847
Willmon
A guanylate kinase/HSV-1 thymi ...
Homo sapiens, Mus musculus
Gene Ther.
13
1309-1312
2006
-
-
-
-
-
-
-
2
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6
-
2
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6
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2
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6
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6
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675894
Abergel
Impact of the excision of an a ...
Rickettsia conorii
Mol. Biol. Evol.
23
2112-2122
2006
-
-
-
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Griffith
The partial purification of de ...
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