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Literature summary for 2.7.4.6 extracted from
- Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers: consequences on G protein activation and stability (2007), Naunyn Schmiedebergs Arch. Pharmacol., 374, 373-383.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in H10 cell membranes | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview | ? | - |
? |  |
| additional information | Homo sapiens | the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P15531 | eight NDPKB isozymes | - |
| Rattus norvegicus | - |
isozyme NDPKB | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme performs autophosphorylation at His118 | Rattus norvegicus |
| phosphoprotein | the enzyme performs autophosphorylation at His118 | Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + nucleoside diphosphate = ADP + nucleoside triphosphate | ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118 | Rattus norvegicus | |
| ATP + nucleoside diphosphate = ADP + nucleoside triphosphate | ping pong mechanism with formation of an enzyme intermediate phosphorylated at His118 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiac myocyte | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + GDP | assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP | Rattus norvegicus | ADP + GTP | - |
r | |
| ATP + GDP | assay by spontaneous release of GDP from G proteins. This GDP serves as a substrate for phosphotransfer by the NDPK, and the formed GTP then binds back to the G protein. NDPK is able to transfer phosphate also onto denatured proteins and thus also on the covalently linked GDP | Homo sapiens | ADP + GTP | - |
r | |
| additional information | the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview | Rattus norvegicus | ? | - |
? | |
| additional information | the transfer of high energetic phosphate by NDPK and/or the beta subunit of G proteins can induce G protein activation. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers influencing the G protein activation and stability, mechanism, detailed overview | Homo sapiens | ? | - |
? | |
| additional information | NDPK B acts as histidine kinase in a NDPK B/Gbetagamma complex, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview. Nucleoside diphosphate kinase is a ubiquitous enzyme that catalyses the transfer of the gamma-phosphate from nucleoside 5'-triphosphates to nucleoside 5'-diphosphates by a ping-pong mechanism involving the formation of a high energy phosphate intermediate on His118 | Rattus norvegicus | ? | - |
? | |
| additional information | NDPK B acts as histidine kinase in a NDPK B/Gbetagamma complex, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview. Nucleoside diphosphate kinase is a ubiquitous enzyme that catalyses the transfer of the gamma-phosphate from nucleoside 5'-triphosphates to nucleoside 5'-diphosphates by a ping-pong mechanism involving the formation of a high energy phosphate intermediate on His118 | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 17000-21000, the cytosolic isozymes form heterohexameric complexes | Rattus norvegicus |
| hexamer | 6 * 17000-21000, the cytosolic isozymes form heterohexameric complexes | Homo sapiens |
| More | three-dimensional structure of NDPK B complexed with a heterotrimeric G protein, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview | Rattus norvegicus |
| More | three-dimensional structure of NDPK B complexed with a heterotrimeric G protein, NDPK B/Gbetagamma complex formation, structure, and mode of action, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NDPK | - |
Homo sapiens |
| NDPKB | - |
Rattus norvegicus |
| NDPKB | - |
Homo sapiens |
| nucleoside diphosphate kinase | - |
Homo sapiens |
| nucleoside diphosphate kinase B | - |
Rattus norvegicus |
| nucleoside diphosphate kinase B | - |
Homo sapiens |
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