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Literature summary for 2.7.4.6 extracted from
- Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase (2003), Cancer Res., 63, 4089-4094.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-fusion NM23 protein in Escherichia coli | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 15000 | - |
x * 15000, SDS-PAGE | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + NDP | Escherichia coli | contributes to the maintenance of the cellular pools of all nucleosides triphosphates | ADP + NTP | - |
? |  |
| ATP + NDP | Homo sapiens | contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins | ADP + NTP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + NDP | - |
Escherichia coli | ADP + NTP | - |
? | |
| ATP + NDP | - |
Homo sapiens | ADP + NTP | - |
? | |
| ATP + NDP | contributes to the maintenance of the cellular pools of all nucleosides triphosphates | Escherichia coli | ADP + NTP | - |
? | |
| ATP + NDP | contributes to the maintenance of the cellular pools of all nucleosides triphosphates, NM23 metastasis suppressor involved in inactivation of oncogenic forms of Ras proteins | Homo sapiens | ADP + NTP | - |
? | |
| GTP-bound Ras protein + NDP | in vitro, inactivation of mutant oncogenic Ras proteins | Escherichia coli | GDP-bound Ras protein + NTP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 15000, SDS-PAGE | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NDK | - |
Homo sapiens |
| NM23 metastasis suppressor | exhibits Ndk activity | Homo sapiens |
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Release 2023.1 (January 2023)
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