Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors | Homo sapiens | |
ATP | adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cytosolic isoforms AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucose | elevated concentrations of glucose inhibit cytosolic isoform AK1 expression. Inhibition of adenylate kinase increases the ATP/ADP ratio in the microenvironment of the K/ATP channel promoting channel closure and insulin secretion | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic islet | cytosolic isoforms AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | cytosolic isoform AK1 immunoprecipitates with the Kir6.2 subunit of K/ATP channel | Homo sapiens |