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Literature summary for 2.7.4.3 extracted from

  • Stanojevic, V.; Habener, J.F.; Holz, G.G.; Leech, C.A.
    Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells (2008), Biochem. Biophys. Res. Commun., 368, 614-619.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
AMP adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors Homo sapiens
ATP adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cytosolic isoforms AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D-glucose elevated concentrations of glucose inhibit cytosolic isoform AK1 expression. Inhibition of adenylate kinase increases the ATP/ADP ratio in the microenvironment of the K/ATP channel promoting channel closure and insulin secretion Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet cytosolic isoforms AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression Homo sapiens
-

Subunits

Subunits Comment Organism
More cytosolic isoform AK1 immunoprecipitates with the Kir6.2 subunit of K/ATP channel Homo sapiens