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Literature summary for 2.7.4.24 extracted from
- Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases (2007), J. Biol. Chem., 282, 30754-30762.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene VIP1, DNA and amino acid sequence determination and analysis, VIP1 expression in mutant yeast, functional expression of CFP- or GST-tagged VIP1 in HEK-293T cells | Homo sapiens |
| gene VIP2, DNA and amino acid sequence determination and analysis, functional expression of CFP- or GST-tagged VIP2 in HEK-293T cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | VIP1 expression in mutant yeast restores IP7 synthesis | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
1D-myo-inositol 5-diphosphate pentakisphosphate | pH 6.2, 37°C, VIP1 | Homo sapiens |  |
| 0.00019 | - |
1D-myo-inositol 5-diphosphate pentakisphosphate | pH 6.2, 37°C, VIP2 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | primarily | Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate | - |
? | |
| additional information | Homo sapiens | VIP1 also performs the reaction of EC 2.7.4.21 | ? | - |
? | |
| additional information | Homo sapiens | VIP2 also performs the reaction of EC 2.7.4.21 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43314 | VIP2 | - |
| Homo sapiens | Q6PFW1 | VIP1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate | - |
? | |
| additional information | VIP1 also performs the reaction of EC 2.7.4.21 | Homo sapiens | ? | - |
? | |
| additional information | VIP2 also performs the reaction of EC 2.7.4.21 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| diphosphoinositol pentakisphosphate kinase | - |
Homo sapiens |
| IP7 kinase | - |
Homo sapiens |
| More | cf. EC 2.7.4.21 | Homo sapiens |
| PP-IP5 kinase | - |
Homo sapiens |
| VIP1 | - |
Homo sapiens |
| VIP2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4 | - |
1D-myo-inositol 5-diphosphate pentakisphosphate | pH 6.2, 37°C, VIP1 | Homo sapiens | |
| 38 | - |
1D-myo-inositol 5-diphosphate pentakisphosphate | pH 6.2, 37°C, VIP2 | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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