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Literature summary for 2.7.4.24 extracted from

  • Huang, C.F.; Voglmaier, S.M.; Bembenek, M.E.; Saiardi, A.; Snyder, S.H.
    Identification and purification of diphosphoinositol pentakisphosphate kinase, which synthesizes the inositol pyrophosphate bis(diphospho)inositol tetrakisphosphate (1998), Biochemistry, 37, 14998-15004.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7
-
diphosphoinositol pentakisphosphate pH 6.8, 37°C Rattus norvegicus
1.39
-
ADP pH 6.8, 37°C Rattus norvegicus
1.89
-
ATP pH 6.8, 37°C Rattus norvegicus
1.94
-
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate pH 6.8, 37°C Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
SDS-PAGE Rattus norvegicus
60000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate Rattus norvegicus
-
ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 50% loss of activity in 20% glycerol after 1 week Rattus norvegicus
-70°C, no loss of activity in 20% glycerol for 3 months Rattus norvegicus
4°C, complete loss of activity within 18 h Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
Rattus norvegicus ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
?
ADP + diphosphoinositol pentakisphosphate enzyme has ATP synthase activity Rattus norvegicus ATP + ?
-
?
ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate
-
Rattus norvegicus ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 56000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 40 70% activity at 25°C and 40°C Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4
-
complete loss of activity within 18 h Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8.5 half maximal acitvity at pH 5.5 and pH 8.5 Rattus norvegicus