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Literature summary for 2.7.4.21 extracted from

  • Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.
    Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport (2016), Biochem. J., 473, 3031-3047.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene IP6K1 Mus musculus
gene IP6K1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of gene Ip6k1 knockout mutant cells Mus musculus
additional information generation of gene Ip6k1 knockout mutant cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Dictyostelium discoideum 5768
-
endosome
-
Mus musculus 5768
-
endosome
-
Homo sapiens 5768
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Dictyostelium discoideum
Mg2+ required Mus musculus
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-
Homo sapiens Q92551
-
-
Mus musculus Q6PD10 gene IP6K1
-
Mus musculus C57BL/6 Q6PD10 gene IP6K1
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-
MEF cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1
-
Dictyostelium discoideum
inositol hexakisphosphate kinase 1
-
Mus musculus
inositol hexakisphosphate kinase 1
-
Homo sapiens
IP6K1
-
Dictyostelium discoideum
IP6K1
-
Mus musculus
IP6K1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Dictyostelium discoideum
ATP
-
Mus musculus
ATP
-
Homo sapiens

General Information

General Information Comment Organism
evolution in Dictyostelium discoideum, the IP7 target Ser is conserved, but the neighboring Asp and Glu residues are replaced with Thr. These Thr residues may undergo phosphorylation to mimic Asp/Glu and create a consensus site for diphosphorylation Dictyostelium discoideum
evolution the absence of diphosphorylation in the IC(1-70)fragment suggests that the Ser-Pro cluster (residues 71-111) is required to facilitate pyrophosphorylation on Ser51. The site of diphosphorylation in mouse IC-2C is well conserved in human and rat, suggesting that the effect of IP7 on dynein is likely to be conserved in these species Mus musculus
evolution the absence of diphosphorylation in the IC(1-70)fragment suggests that the Ser-Pro cluster (residues 71-111) is required to facilitate pyrophosphorylation on Ser51. The site of diphosphorylation in mouse IC-2C is well conserved in human and rat, suggesting that the effect of IP7 on dynein is likely to be conserved in these species Homo sapiens
malfunction endosomes derived from slime mold lacking inositol diphosphates display reduced dynein-directed microtubule transport. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1 Dictyostelium discoideum
malfunction mammalian cells lacking IP6K1 display defects in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement, and Golgi maintenance. Expression of catalytically active but not inactive IP6K1 reverses the defects. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1 Homo sapiens
malfunction mammalian cells lacking IP6K1 display defects in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement, and Golgi maintenance. Expression of catalytically active but not inactive IP6K1 reverses the defects. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1. Decreased Tfn distribution in the ERC in Ip6k1-/- MEFs might be due to a delay in Tfn trafficking from endosomes. Tfn is held back in early endosomes in cells lacking IP6K1 Mus musculus
physiological function generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. Endosomal sorting of Tfn in fibroblasts requires IP6K1 activity, the enzyme activity also is required to maintain Golgi morphology. IP6K1 activity regulates Tfn trafficking, overview Mus musculus
physiological function generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. IP6K1 activity regulates Tfn trafficking, overview Homo sapiens
physiological function generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. Phagosomal motility requires IP6K1. IP6K1 activity regulates Tfn trafficking, overview Dictyostelium discoideum