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Literature summary for 2.7.4.21 extracted from

  • Bhandari, R.; Juluri, K.R.; Resnick, A.C.; Snyder, S.H.
    Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis (2008), Proc. Natl. Acad. Sci. USA, 105, 2349-2353.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene Ihpk1, located on chromosome 9, has 6 exons, of which exon 1 is exclusively noncoding, the start codon is located in exon 2, and the stop codon is located in exon 6, DNA and amino acid sequence determination and analysis. Expressionin MEF cell lines Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information gene deletion of IP6K1 in mice leads to markedly diminished production of inositol diphosphates. Male mutant mice are sterile with defects in spermiogenesis. Mutant mice are smaller than wild-type despite normal food intake. The mutants display markedly lower circulating insulin, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
nucleus
-
Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene Ihpk1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
Mus musculus ADP + diphosphoinositol pentakisphosphate + bisdiphosphoinositol tetrakisphosphate
-
?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1
-
Mus musculus
IP6K1
-
Mus musculus
More IP6K1 belongs to the family of inositol hexakisphosphate kinases Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus